Abstract
Fourteen potentially bioactive pyridines, pendant to pyrazole moiety, were synthesized and evaluated in vitro for their antimicrobial potential. Treatment of 2-bromo-1-(5-methyl-1-phenyl-1H-pyrazol-4-yl) ethanone with pyridine afforded the corresponding pyridinium bromide salt. Reaction of the latter salt with alpha,beta-unsaturated ketones yielded the corresponding 2,4,6-trisubstituted pyridine derivatives. The structures of the synthesized products were confirmed by all possible spectral data. The antimicrobial activity of some selected products was evaluated by using well-diffusion agar assay and minimum inhibitory concentration determination, and the results revealed good-to-moderate activities compared with reference drugs.