Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet; Josep M Anto; Peter J Sterk; Ian M Adcock; Kian Fan Chung; Josep Roca; Alvar Agusti; Chris Brightling; Anne Cambon-Thomsen; Alfredo Cesario; Sonia Abdelhak; Stylianos E Antonarakis; Antoine Avignon; Andrea Ballabio; Eugenio Baraldi; Alexander Baranov; Thomas Bieber; Joël Bockaert; Samir Brahmachari; Christian Brambilla; Jacques Bringer; Michel Dauzat; Ingemar Ernberg; Leonardo Fabbri; Philippe Froguel; David Galas; Takashi Gojobori; Peter Hunter; Christian Jorgensen; Francine Kauffmann; Philippe Kourilsky; Marek L Kowalski; Doron Lancet; Claude Le Pen; Jacques Mallet; Bongani Mayosi; Jacques Mercier; Andres Metspalu; Joseph H Nadeau; Grégory Ninot; Denis Noble; Mehmet Öztürk; Susanna Palkonen; Christian Préfaut; Klaus Rabe; Eric Renard; Richard G Roberts; Boleslav Samolinski; Holger J Schünemann; Hans-Uwe Simon; Marcelo Bento Soares; Giulio Superti-Furga; Jesper Tegner; Sergio Verjovski-Almeida; Peter Wellstead; Olaf Wolkenhauer; Emiel Wouters; Rudi Balling; Anthony J Brookes; Dominique Charron; Christophe Pison; Zhu Chen; Leroy Hood; Charles Auffray

doi:10.1186/gm259

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Systems medicine and integrated care to combat chronic noncommunicable diseases

Journal article

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Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet, Josep M Anto, Peter J Sterk, Ian M Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, …

Genome medicine, Vol.3(7), pp.43-43

01/01/2011

DOI: https://doi.org/10.1186/gm259

PMCID: PMC3221551

PMID: 21745417

Abstract

Correspondence

We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems.

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Title: Systems medicine and integrated care to combat chronic noncommunicable diseases
Creators - without role: Jean Bousquet - Hôpital Arnaud de Villeneuve
Josep M Anto - Pompeu Fabra University
Peter J Sterk - University of Amsterdam
Ian M Adcock - Imperial College London
Kian Fan Chung - Imperial College London
Josep Roca - Universitat de Barcelona
Alvar Agusti - Universitat de Barcelona
Chris Brightling - National University of Ireland, Maynooth
Anne Cambon-Thomsen - Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps
Alfredo Cesario - IRCCS Ospedale San Raffaele
Sonia Abdelhak - Institut Pasteur de Tunis
Stylianos E Antonarakis - University of Geneva
Antoine Avignon - University Hospital of Montpellier
Andrea Ballabio - Telethon Institute Of Genetics And Medicine
Eugenio Baraldi - University of Padua
Alexander Baranov - National University of Ireland, Maynooth
Thomas Bieber - University of Bonn
Joël Bockaert - Institut de Génomique Fonctionnelle
Samir Brahmachari - Institute of Genomics and Integrative Biology
Christian Brambilla - Institute for Advanced Biosciences
Jacques Bringer - Hôpital Lapeyronie
Michel Dauzat - University of Nîmes
Ingemar Ernberg - Karolinska Institutet
Leonardo Fabbri - University of Modena and Reggio Emilia
Philippe Froguel - Imperial College London
David Galas - Institute for Systems Biology
Takashi Gojobori - National Institute of Genetics
Peter Hunter - University of Auckland
Christian Jorgensen - Inserm
Francine Kauffmann - Centre de recherche en Epidémiologie et Santé des Populations
Philippe Kourilsky - Singapore Immunology Network
Marek L Kowalski - Medical University of Lodz
Doron Lancet - Weizmann Institute of Science
Claude Le Pen - National University of Ireland, Maynooth
Jacques Mallet - National University of Ireland, Maynooth
Bongani Mayosi - Groote Schuur Hospital
Jacques Mercier - University of Montpellier
Andres Metspalu - University of Tartu
Joseph H Nadeau - Institute for Systems Biology
Grégory Ninot - National University of Ireland, Maynooth
Denis Noble - University of Oxford
Mehmet Öztürk - Bilkent University
Susanna Palkonen - European Federation of Allergy and Airways Diseases Patients Associations
Christian Préfaut - University of Montpellier
Klaus Rabe - Kiel University
Eric Renard - Hôpital Lapeyronie
Richard G Roberts - University of Wisconsin–Madison
Boleslav Samolinski - National University of Ireland, Maynooth
Holger J Schünemann - McMaster University
Hans-Uwe Simon - University of Bern
Marcelo Bento Soares - Northwestern University
Giulio Superti-Furga - National University of Ireland, Maynooth
Jesper Tegner - Karolinska Institutet
Sergio Verjovski-Almeida - Universidade de São Paulo
Peter Wellstead - National University of Ireland, Maynooth
Olaf Wolkenhauer - University of Rostock
Emiel Wouters - National University of Ireland, Maynooth
Rudi Balling - University of Luxembourg
Anthony J Brookes - University of Leicester
Dominique Charron - Inserm
Christophe Pison - Joseph Fourier University
Zhu Chen - National University of Ireland, Maynooth
Leroy Hood - Institute for Systems Biology
Charles Auffray - Inserm
Publication Details: Genome medicine, Vol.3(7), pp.43-43
Publisher: BioMed Central
Identifiers: 9945494108331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article