Abstract
The protective effect of
l-carnitine or coenzyme Q10 (CoQ10) against high magnetic field (20
mT) induced testicular toxicity in mice were evaluated. Animals were injected with
l-carnitine (200
mg
kg
−1, i.p.) or CoQ10 (200
mg
kg
−1, p.o.) 1
h before exposure to fractionated doses (30
min per day, three times per week for 2 weeks) or acute dose (3
h) of magnetic field. Total sperm count, motility, daily sperm production, and testicular LDH-X activity as well as histopathological examination were investigated. Exposure of mice to fractionated doses of magnetic field caused a significant decrease in sperm count, motility, daily sperm production, and LDH-X activity, which was more pronounced than that of acute dose. Moreover, a marked testicular histopathological changes were observed after exposure to fractionated doses of magnetic field. Pretreatment of mice with
l-carnitine or CoQ10 1
h before exposure to magnetic field caused a significant recovery of mice testes damage induced by high magnetic field (20
mT).