Abstract
Anticancer drug cysplatin was injected at a dose of 6 mg/kg into intact rats and those with Gurein carcinoma, sensitive and resistant to the drug. The dynamics of the drug action on the lipid peroxidation in blood plasma and cell membranes of hepatocytes and tumor cells was studied. The lipid peroxidation intensity was evaluated by the malonic dialdehyde accumulation and induced chemiluminescence. The decrease of induced chemiluminescence intensity of hepatocytes' plasma membranes occurred in the animals with sensitive tumors as compared with those with resistant tumors and intact. The dynamics of alterations of the studied parameters varied significantly in the different groups within 96 h after the drug injection. It is suggested that both the processes of the resistance development and those related to the drug action are accompanied by the alterations of structural and functional properties of plasma membranes of tumor cells as well as host's hepatocytes.