Abstract
Assessment of intermediate coronary lesions with diameter stenosis of 40% to 70% severity is being a challenge for cardiologist to identify potentially ischemic stenosis for revascularization and nonculprit stenosis which can be deferred from stenting. An invasive coronary angiography and intravascular ultrasound provide anatomic information of stenosis severity whereas an invasive fractional flow reserve index (FFR) provides the functional significance of the stenosis severity. The measurement of functional significance of stenosis severity minimizes the procedural complications such as coronary dissection, in stent restenosis etc. rather than anatomical significance measure. The FFR cutoff value of <=\ 0.8 is used to distinguish ischemic and nonischemic stenosis. The FFR is clinically well validated even though it is influenced by the mechanical factors such as hyperemic flow and guide wire insertion. In recent times, noninvasive coronary computed tomography (CCTA) modality has become popular in the diagnosis of coronary artery disease. The CCTA permits the assessment of cross-sectional parameters such as minimum lumen area and lumen diameter, lesion length and plaque morphology. However, the CCTA provides limited information on the functional significance of stenotic lesions as compared to FFR. The purpose of this review is to discuss the mechanical factors influencing the invasive FFR while assessing the functional significance of intermediate stenosis severity. In addition, the hidden mechanical factors influencing the noninvasive CCTA assessment of stenosis severity will be discussed from the critical information obtained from FFR which could be beneficial for the clinician particularly in the assessment of intermediate stenosis severity.