Abstract
Type 3c diabetes mellitus or pancreatogenic diabetes mellitus is usually misdiagnosed as type 2 diabetes and they may co-exist. Type 2 diabetes is approaching an epidemic worldwide, thus a considerable proportion may be due to type 3c diabetes mellitus. In addition to insulin deficiency, glucagon and pancreatic polypeptide are also lost in type 3 diabetes, so these patients are more prone to hypoglycemia on one hand and a higher microvascular complication on the other hands. Furthermore, failure to introduce the proper treatment in a timely appropriate manner may complicate the matter further with deleterious consequences. Type 3c diabetes mellitus needs a special consideration regarding the diagnosis and management, thus we conducted this review. A systematic manual search was conducted in PubMed and Google Scholar database, articles in English language published from 2009 up to October 2018 were retrieved using type 3c diabetes, pancreatogenous diabetes, pancreatectomy and type 3c diabetes, pancreatitis and type 3c diabetes, and pancreatic cancer and type 3c diabetes, . A total of 209 manuscripts were found, 28 articles were approached after removing irrelevant articles and duplication. In this review we discuss the prevalence, pathophysiology, causes, the diagnosis, and management of this common morbid disease.