Abstract
Diabetes mellitus is one of the foremost concerns in high as well as low-middle income nations. Around 45% of cases of pancreatic carcinoma are expected to appear as incident cases of diabetes mellitus; nevertheless, the type of relationship between type two diabetes mellitus and pancreatic carcinoma is however controversial. Therefore, we carried out a narrative review to synthesize the findings of the relationship between diabetes mellitus and cancer of the pancreas.
We approached Google Scholar and PubMed to carry out the searches for relevant articles. We undertook a narrative review of eligible research articles that were available in the English language in developed and developing countries from 2015 to 2020. All primary research articles were examined for information pertinent to the objective. All references of the eligible articles were also reviewed to make sure to include all relevant articles in the review.
The included studies explored the association between diabetes mellitus and malignancy of the pancreas. We found the results of the review to be supportive of our hypothesis. Numerous biologic pathways and processes have been highlighted as a shred of evidence that alludes to the association between diabetes mellitus and malignancy of the pancreas. Abnormalities in metabolism, immunologic pathways, and hormonal features of diabetes mellitus may increase the risk of cancer development.
Further, studies have shown that increased production of insulin and insulin-like growth factors may increase the probability of malignancy of the pancreas by upregulating cellular proliferation and thereby abnormal cancerous cells.
There is evidence that shows that diabetes mellitus increases the risk of several cancers such as malignancy of the pancreas. On the basis of the evidence from this review, it is recommended for clinicians to screen people for diabetes mellitus and also monitor the existing patients with diabetes mellitus to.screen for pancreatic cancer in a timely manner.