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Tandem Chlorination - Oxidation - Wittig Reactions: An Efficient Approach to (Z)-alpha-chloro-alpha,beta-unsaturated esters
Journal article   Peer reviewed

Tandem Chlorination - Oxidation - Wittig Reactions: An Efficient Approach to (Z)-alpha-chloro-alpha,beta-unsaturated esters

Mujeeb Abdullah Sultan, Hana'a Al-Shamari, Hoda Abdelall, Abdulrahman Ibrahim Almansour and Usama Karama
Journal of the Chemical Society of Pakistan, Vol.39(1), pp.92-96
01/02/2017

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
In this study, a series of the (Z)-alpha-chloro-alpha,beta-unsaturated esters 3 were efficiently prepared in a one-pot sequence. In the presence of N-chlorosuccinimide (NCS) and manganese dioxide, under ultrasonication conditions, (carboethoxymethylene) triphenylphosphorane 1 underwent tandem chlorination/oxidation/Wittig olefination sequence with the activated alcohol 2, to afford (Z)-alpha-chloro-alpha, beta-unsaturated esters in moderate to good yields.

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