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Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus
Journal article   Peer reviewed

Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus

Diaa T A Youssef
Journal of natural products (Washington, D.C.), Vol.67(1), pp.112-114
01/01/2004
DOI: https://doi.org/10.1021/np0340192
PMID: 14738401

Abstract

Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Drug Screening Assays, Antitumor Humans Indian Ocean Mice Molecular Structure Peroxides - chemistry Peroxides - isolation & purification Peroxides - pharmacology Porifera - chemistry Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Tumor Cells, Cultured
Tasnemoxides A-C (1-3), three new cytotoxic cyclic norsestertepene peroxides, were isolated from the Red Sea sponge Diacarnus erythraenus, together with the known compound sigmosceptrellin B (4). The structural determination of the isolated compounds was based on extensive 1D and 2D NMR studies and mass spectral determinations. Compounds 1-3 showed moderate cytotoxicity against three cancer cell lines.

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