Abstract
Each of 18 patients with giant papillary conjunctivitis induced by contact lenses had symptoms of increased mucous production with blurred vision, decreased contact lens tolerance, pruritus, and giant papillae of the upper tarsal conjunctiva. Tear IgE levels in patients with giant papillary conjunctivitis were significantly increased, especially in the more symptomatic eye. Increased tear IgG levels were found in the more symptomatic eyes of patients with giant papillary conjunctivitis. In eight of the 18 patients, tear IgM was measurable, whereas none of the control groups had detectable amounts of IgM in their tears.