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Teriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient
Journal article   Peer reviewed

Teriparatide Therapy for Denosumab-Induced Osteonecrosis of the Jaw in a Male Osteoporotic Patient

Audrey Neuprez, E. Rompen, J. M. Crielaard and Jean-Yves Reginster
Calcified tissue international, Vol.95(1), pp.94-96
01/07/2014
PMID: 24804929

Abstract

Endocrinology & Metabolism Life Sciences & Biomedicine Science & Technology
We report the first case of teriparatide adjuvant role in the management of a denosumab-induced osteonecrosis of the jaw in a male subject with idiopathic osteoporosis. Clinical benefits and CT healing were obtained within 2 months of teriparatide initiation and denosumab withdrawal. Increase in bone turnover previously described, when denosumab treatment is removed, might have a synergistic effect to the stimulating effect of teriparatide on bone remodeling to promptly heal osteonecrosis of the jaw.

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