Abstract
:
Fungi are considered a prosperous pool of microbial bio-metabolites. Terretonins are meroterpenoids
that are reported mainly from the Aspergillus genus. They exhibit unique tetracyclic core
skeletons and various bioactivities. The current review summarizes the published researches on the
source, biosynthesis, isolation, structural characterization, and bioactivities of terretonins that have been
reported from Aspergillus species, as well as from synthetic sources. A literature search on the published
studies was conducted over different databases, including Web of Science, MedLine (PubMed),
Scopus, SpringerLink, Google Scholar, SciFinder, Wiley, and ACS Publications up to 2020. In this
work, 18 compounds from Aspergillus species and synthetic sources are depicted. They have unrivaled
and diversified skeletons as well as various bioactivities. Moreover, 37 references are included. Terretonins
form a class of fungal bio-metabolites that attain all the characters for becoming lead compounds
in their particular therapeutic category.