Abstract
A new series of platinum(II) complexes based on thione ligands with general formula [Pt(thione)
4
]X
2
(X
−
= Cl
−
, NO
3
−
) has been synthesized and characterized using CHNS elemental analysis, infrared,
1
H and
13
C solution-state NMR as well as
13
C and
15
N solid-state NMR spectroscopy, and X-ray crystallography. The spectroscopic methods confirm the coordination of Pt(II) with thiocarbonyl groups via sulfur of the thione ligands. The X-ray structures showed a distorted square planar geometry for 1, [Pt(MeImt)
4
]Cl
2
(MeImt = N-Methylimidazolidine-2-thione) while the hydrogen bonding interactions in 7, [Pt(iPrImt)
4
](NO
3
)
2
·0.6(H
2
O) induce a bent see-saw distortion relative to the ideal square planar geometry. The in vitro cytotoxicity studies showed that 2, [Pt(EtImt)
4
]Cl
2
is generally the most effective, a two-fold better cytotoxic agent than cisplatin and carboplatin against MCF7 (human breast cancer).