Abstract
The title compound tetraphenylborate salt of bambuterol (Bambec(A (R))), N-(2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)-2-hydroxyethyl)-2-methylpropan-2-aminium tetraphenylborate (4), was prepared in 73 % yield by the reaction of 5-(2-(tert-butylamino)-1-hydroxyethyl)-1,3-phenylene bis(dimethylcarbamate) hydrochloride (bambuterol hydrochloride) (2) with sodium tetraphenylborate (3) in deionized water, at ambient temperature, through anion exchange reaction. The structure of the title borate salt was characterized by IR, mass and H-1 NMR analyses. Colorless crystals of 4 suitable for an X-ray structural analysis were obtained by slow evaporation from acetonitrile. Compound 4 crystallizes in the monoclinic, space group P2(1)/c, with a = 8.8931 (2) , b = 20.4639 (6) , c = 21.4393 (6) , beta = 93.640 (2)A degrees, V = 3893.81 (18) (3), Z = 4.
Synthesis, characterization and X-ray structure of tetraphenylborate salt of bambuterol (Bambec(A (R))), the drug for the treatment of asthma, bronchospasm, emphysema, and chronic obstructive pulmonary disease.