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The BRAF Inhibitor Vemurafenib Enhances UV-Induced Skin Carcinogenesis in Beta HPV38 E6 and E7 Transgenic Mice
Journal article   Open access  Peer reviewed

The BRAF Inhibitor Vemurafenib Enhances UV-Induced Skin Carcinogenesis in Beta HPV38 E6 and E7 Transgenic Mice

Daniele Viarisio, Karin Müller-Decker, Jessica C Hassel, Jean-Claude Alvarez, Christa Flechtenmacher, Michael Pawlita, Lutz Gissmann and Massimo Tommasino
Journal of investigative dermatology, Vol.137(1), pp.261-264
01/2017
DOI: https://doi.org/10.1016/j.jid.2016.08.030
PMID: 27650607

Abstract

Animals Antineoplastic Agents - adverse effects Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - etiology Carcinoma, Squamous Cell - pathology Cocarcinogenesis - drug effects Cocarcinogenesis - radiation effects Disease Models, Animal Humans Indoles - adverse effects Melanoma - drug therapy Mice Mice, Transgenic Papillomaviridae - pathogenicity Papillomavirus E7 Proteins - genetics Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Skin Neoplasms - drug therapy Skin Neoplasms - etiology Skin Neoplasms - pathology Sulfonamides - adverse effects Ultraviolet Rays - adverse effects Vemurafenib
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https://doi.org/10.1016/j.jid.2016.08.030View
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