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The Baylis-Hillman reaction of substituted aminomethylbenzotriazoles
Journal article   Open access  Peer reviewed

The Baylis-Hillman reaction of substituted aminomethylbenzotriazoles

Alan R. Katritzky, Myong Sang Kim and Khalid Widyan
ARKIVOC free online journal of organic chemistry, Vol.2008(3), pp.91-101
01/01/2008

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Aminomethylbenzotriazoles react as effective Baylis-Hillman electrophiles with ethyl acrylate in the presence of TiCl4 at 20 degrees C to afford the corresponding benzotriazolated adducts in 66-80% yield. These adducts are (i) readily transformed to the Baylis-Hillman olefins by sodium hydride and (ii) smoothly undergo substitution of Bt with thiols.
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https://doi.org/10.3998/ark.5550190.0009.310View
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