Abstract
OBJECTIVE: The COVID-19 vac-cination has been linked to numerous reports of menstrual disorders as potential side effects. However, menstrual cycle results after vaccination were not collected throughout clinical trials. Ac-cording to other research, COVID-19 vaccination and menstrual disorders have no discernible con-nection, and menstrual disorders are temporary. SUBJECTS AND METHODS: We asked ques-tions about menstruation disturbances follow-ing the first and second doses of the COVID-19 vaccine in a population-based cohort of adult Saudi women to determine whether the vaccina-tion is linked to menstrual cycle irregularities. RESULTS: According to the results, 63.9% of women experienced variations in their menstrual cycle either after the first or second dose. Such results show that COVID-19 vaccination impacts women's menstrual cycles. However, there is no need for concern because the alterations are rel-atively minor, and the menstrual cycle usually re-turns to normal within two months. Additional-ly, there are no obvious distinctions between the various vaccine types or body mass.CONCLUSIONS: Our findings support and ex-plain the self-reports of menstrual cycle vari-ations. We have discussed reasons for these problems that describe the mechanism of the relationship between them and the immune re-sponse. Such reasons will help prevent hormon-al imbalances and the influence of therapies and immunizations on the reproductive system.