The DNA sequence and analysis of human chromosome 13

A Dunham; L H Matthews; J Burton; J L Ashurst; K L Howe; K J Ashcroft; D M Beare; D C Burford; S E Hunt; S Griffiths-Jones; M C Jones; S J Keenan; K Oliver; C E Scott; R Ainscough; J P Almeida; K D Ambrose; D T Andrews; RIS Ashwell; A K Babbage; C L Bagguley; J Bailey; R Bannerjee; K F Barlow; K Bates; H Beasley; C P Bird; S Bray-Allen; A J Brown; J Y Brown; W Burrill; C Carder; N P Carter; J C Chapman; M E Clamp; S Y Clark; G Clarke; C M Clee; SCM Clegg; Cobley; J E Collins; N Corby; G J Coville; P Deloukas; P Dhami; Dunham; M Dunn; M E Earthrowl; A G Ellington; L Faulkner; A G Frankish; J Frankland; L French; P Garner; J Garnett; JGR Gilbert; C J Gilson; J Ghori; D V Grafham; S M Gribble; C Griffiths; R E Hall; S Hammond; J L Harley; E A Hart; P D Heath; P J Howden; E J Huckle; P J Hunt; A R Hunt; C Johnson; D Johnson; M Kay; A M Kimberley; A King; G K Laird; C J Langford; S Lawlor; D A Leongamornlert; D M Lloyd; C Lloyd; J E Loveland; J Lovell; S Martin; M Mashreghi-Mohammadi; S J McLaren; A McMurray; S Milne; MJF Moore; T Nickerson; S A Palmer; A V Pearce; A I Peck; S Pelan; B Phillimore; K M Porter; C M Rice; S Searle; H K Sehra; R Shownkeen; C D Skuce; M Smith; C A Steward; N Sycamore; J Tester; D W Thomas; A Tracey; A Tromans; B Tubby; M Wall; J M Wallis; A P West; S L Whitehead; D L Willey; L Wilming; P W Wray; M W Wright; L Young; A Coulson; R Durbin; T Hubbard; J E Sulston; S Beck; D R Bentley; J Rogers; M T Ross

doi:10.1038/nature02379

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The DNA sequence and analysis of human chromosome 13

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The DNA sequence and analysis of human chromosome 13

A Dunham, L H Matthews, J Burton, J L Ashurst, K L Howe, K J Ashcroft, D M Beare, D C Burford, S E Hunt, S Griffiths-Jones, …

Nature (London), Vol.428(6982), pp.522-528

01/04/2004

DOI: https://doi.org/10.1038/nature02379

PMCID: PMC2665288

PMID: 15057823

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.

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Title: The DNA sequence and analysis of human chromosome 13
Creators - without role: A Dunham - Wellcome Sanger Institute
L H Matthews - Wellcome Sanger Institute
J Burton - Wellcome Sanger Institute
J L Ashurst - Wellcome Sanger Institute
K L Howe - Wellcome Sanger Institute
K J Ashcroft - Wellcome Sanger Institute
D M Beare - Wellcome Sanger Institute
D C Burford - Wellcome Sanger Institute
S E Hunt - Wellcome Sanger Institute
S Griffiths-Jones - Wellcome Sanger Institute
M C Jones - Wellcome Sanger Institute
S J Keenan - Wellcome Sanger Institute
K Oliver - Wellcome Sanger Institute
C E Scott - Wellcome Sanger Institute
R Ainscough - Wellcome Sanger Institute
J P Almeida - Wellcome Sanger Institute
K D Ambrose - Wellcome Sanger Institute
D T Andrews - Wellcome Sanger Institute
RIS Ashwell
A K Babbage - Wellcome Sanger Institute
C L Bagguley - Wellcome Sanger Institute
J Bailey - Wellcome Sanger Institute
R Bannerjee - Wellcome Sanger Institute
K F Barlow - Wellcome Sanger Institute
K Bates - Wellcome Sanger Institute
H Beasley - Wellcome Sanger Institute
C P Bird - Wellcome Sanger Institute
S Bray-Allen - Wellcome Sanger Institute
A J Brown - Wellcome Sanger Institute
J Y Brown - Wellcome Sanger Institute
W Burrill - Wellcome Sanger Institute
C Carder - Wellcome Sanger Institute
N P Carter - Wellcome Sanger Institute
J C Chapman - Wellcome Sanger Institute
M E Clamp - Wellcome Sanger Institute
S Y Clark - Wellcome Sanger Institute
G Clarke - Wellcome Sanger Institute
C M Clee - Wellcome Sanger Institute
SCM Clegg - Wellcome Sanger Institute
Cobley
J E Collins - Wellcome Sanger Institute
N Corby - Wellcome Sanger Institute
G J Coville - Wellcome Sanger Institute
P Deloukas - Wellcome Sanger Institute
P Dhami - Wellcome Sanger Institute
Dunham
M Dunn - Wellcome Sanger Institute
M E Earthrowl - Wellcome Sanger Institute
A G Ellington - Wellcome Sanger Institute
L Faulkner - Wellcome Sanger Institute
A G Frankish - Wellcome Sanger Institute
J Frankland - Wellcome Sanger Institute
L French - Wellcome Sanger Institute
P Garner - Wellcome Sanger Institute
J Garnett - Wellcome Sanger Institute
JGR Gilbert
C J Gilson - Wellcome Sanger Institute
J Ghori - Wellcome Sanger Institute
D V Grafham - Wellcome Sanger Institute
S M Gribble - Wellcome Sanger Institute
C Griffiths - Wellcome Sanger Institute
R E Hall - Wellcome Sanger Institute
S Hammond - Wellcome Sanger Institute
J L Harley - Wellcome Sanger Institute
E A Hart - Wellcome Sanger Institute
P D Heath - Wellcome Sanger Institute
P J Howden - Wellcome Sanger Institute
E J Huckle - Wellcome Sanger Institute
P J Hunt - Wellcome Sanger Institute
A R Hunt - Wellcome Sanger Institute
C Johnson - Wellcome Sanger Institute
D Johnson - Wellcome Sanger Institute
M Kay - Wellcome Sanger Institute
A M Kimberley - Wellcome Sanger Institute
A King - Wellcome Sanger Institute
G K Laird - Wellcome Sanger Institute
C J Langford - Wellcome Sanger Institute
S Lawlor - Wellcome Sanger Institute
D A Leongamornlert - Wellcome Sanger Institute
D M Lloyd - Wellcome Sanger Institute
C Lloyd - Wellcome Sanger Institute
J E Loveland - Wellcome Sanger Institute
J Lovell - Wellcome Sanger Institute
S Martin - Wellcome Sanger Institute
M Mashreghi-Mohammadi - Wellcome Sanger Institute
S J McLaren - Wellcome Sanger Institute
A McMurray - Wellcome Sanger Institute
S Milne - Wellcome Sanger Institute
MJF Moore
T Nickerson - Wellcome Sanger Institute
S A Palmer - Wellcome Sanger Institute
A V Pearce - Wellcome Sanger Institute
A I Peck - Wellcome Sanger Institute
S Pelan - Wellcome Sanger Institute
B Phillimore - Wellcome Sanger Institute
K M Porter - Wellcome Sanger Institute
C M Rice - Wellcome Sanger Institute
S Searle - Wellcome Sanger Institute
H K Sehra - Wellcome Sanger Institute
R Shownkeen - Wellcome Sanger Institute
C D Skuce
M Smith
C A Steward
N Sycamore
J Tester
D W Thomas
A Tracey
A Tromans
B Tubby
M Wall
J M Wallis
A P West
S L Whitehead
D L Willey
L Wilming
P W Wray
M W Wright
L Young
A Coulson
R Durbin
T Hubbard
J E Sulston
S Beck
D R Bentley
J Rogers
M T Ross
Publication Details: Nature (London), Vol.428(6982), pp.522-528
Publisher: Springer Nature
Number of pages: 7
Identifiers: 9940635908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article