Abstract
Haloxylon salicornicum (H. salicornicum) is commonly used traditionally in treatment of inflammatory disorders. The aim of this study was to assess the effects of aerial parts of H. salicornicum against acute and sub-acute of inflammation in rat models. The models used were acute and sub-acute inflammations of rat paw induced by sub planter administration of carrageenan, and the granuloma-pouch bioassay at the dorsum of rats induced by turpentine oil. Additionally, the phytoconstituents of the studied extract was also investigated. H. salicornicum extracts significantly reduced inflammations in both phases acute model. Moreover, the activity in carrageenan induced sub-acute edema test in a dose-dependent manner. The methanolic extracts of H. salicornicum exhibited a significant reduction in exudate formation in granulomapouch bioassay. It could be concluded that the study verifies traditional use of H. salicornicum extracts for alleviating acute and sub-acute inflammatory disorders.