The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W Winkler; Anne E Justice; Mariaelisa Graff; Llilda Barata; Mary F Feitosa; Su Chu; Jacek Czajkowski; Tõnu Esko; Tove Fall; Tuomas O Kilpeläinen; Yingchang Lu; Reedik Mägi; Evelin Mihailov; Tune H Pers; Sina Rüeger; Alexander Teumer; Georg B Ehret; Teresa Ferreira; Nancy L Heard-Costa; Juha Karjalainen; Vasiliki Lagou; Anubha Mahajan; Michael D Neinast; Inga Prokopenko; Jeannette Simino; Tanya M Teslovich; Rick Jansen; Harm-Jan Westra; Charles C White; Devin Absher; Tarunveer S Ahluwalia; Shafqat Ahmad; Eva Albrecht; Alexessander Couto Alves; Jennifer L Bragg-Gresham; Anton J M de Craen; Joshua C Bis; Amélie Bonnefond; Gabrielle Boucher; Gemma Cadby; Yu-Ching Cheng; Charleston W K Chiang; Graciela Delgado; Ayse Demirkan; Nicole Dueker; Niina Eklund; Gudny Eiriksdottir; Joel Eriksson; Bjarke Feenstra; Krista Fischer; Francesca Frau; Tessel E Galesloot; Frank Geller; Anuj Goel; Mathias Gorski; Tanja B Grammer; Stefan Gustafsson; Saskia Haitjema; Jouke-Jan Hottenga; Jennifer E Huffman; Anne U Jackson; Kevin B Jacobs; Åsa Johansson; Marika Kaakinen; Marcus E Kleber; Jari Lahti; Irene Mateo Leach; Benjamin Lehne; Youfang Liu; Ken Sin Lo; Mattias Lorentzon; Jian'an Luan; Pamela A F Madden; Massimo Mangino; Barbara McKnight; Carolina Medina-Gomez; Keri L Monda; May E Montasser; Gabriele Müller; Martina Müller-Nurasyid; Ilja M Nolte; Kalliope Panoutsopoulou; Laura Pascoe; Lavinia Paternoster; Nigel W Rayner; Frida Renström; Federica Rizzi; Lynda M Rose; Kathy A Ryan; Perttu Salo; Serena Sanna; Hubert Scharnagl; Jianxin Shi; Albert Vernon Smith; Lorraine Southam; Alena Stančáková; Valgerdur Steinthorsdottir; Rona J Strawbridge; Yun Ju Sung; Ioanna Tachmazidou; Toshiko Tanaka; Gudmar Thorleifsson; Stella Trompet; Natalia Pervjakova; Jonathan P Tyrer; Liesbeth Vandenput; Sander W van der Laan; Nathalie van der Velde; Jessica van Setten; Jana V van Vliet-Ostaptchouk; Niek Verweij; Efthymia Vlachopoulou; Lindsay L Waite; Sophie R Wang; Zhaoming Wang; Sarah H Wild; Christina Willenborg; James F Wilson; Andrew Wong; Jian Yang; Loïc Yengo; Laura M Yerges-Armstrong; Lei Yu; Weihua Zhang; Jing Hua Zhao; Ehm A Andersson; Stephan J L Bakker; Damiano Baldassarre; Karina Banasik; Matteo Barcella; Cristina Barlassina; Claire Bellis; Paola Benaglio; John Blangero; Matthias Blüher; Fabrice Bonnet; Lori L Bonnycastle; Heather A Boyd; Marcel Bruinenberg; Aron S Buchman; Harry Campbell; Yii-Der Ida Chen; Peter S Chines; Simone Claudi-Boehm; John Cole; Francis S Collins; Eco J C de Geus; Lisette C P G M de Groot; Maria Dimitriou; Jubao Duan; Stefan Enroth; Elodie Eury; Aliki-Eleni Farmaki; Nita G Forouhi; Nele Friedrich; Pablo V Gejman; Bruna Gigante; Nicola Glorioso; Alan S Go; Omri Gottesman; Jürgen Gräßler; Harald Grallert; Niels Grarup; Yu-Mei Gu; Linda Broer; Annelies C Ham; Torben Hansen; Tamara B Harris; Catharina A Hartman; Maija Hassinen; Nicholas Hastie; Andrew T Hattersley; Andrew C Heath; Anjali K Henders; Dena Hernandez; Hans Hillege; Oddgeir Holmen; Kees G Hovingh; Jennie Hui; Lise L Husemoen; Nina Hutri-Kähönen; Pirro G Hysi; Thomas Illig; Philip L De Jager; Shapour Jalilzadeh; Torben Jørgensen; J Wouter Jukema; Markus Juonala; Stavroula Kanoni; Maria Karaleftheri; Kay Tee Khaw; Leena Kinnunen; Steven J Kittner; Wolfgang Koenig; Ivana Kolcic; Peter Kovacs; Nikolaj T Krarup; Wolfgang Kratzer; Janine Krüger; Diana Kuh; Meena Kumari; Theodosios Kyriakou; Claudia Langenberg; Lars Lannfelt; Chiara Lanzani; Vaneet Lotay; Lenore J Launer; Karin Leander; Jaana Lindström; Allan Linneberg; Yan-Ping Liu; Stéphane Lobbens; Robert Luben; Valeriya Lyssenko; Satu Männistö; Patrik K Magnusson; Wendy L McArdle; Cristina Menni; Sigrun Merger; Lili Milani; Grant W Montgomery; Andrew P Morris; Narisu Narisu; Mari Nelis; Ken K Ong; Aarno Palotie; Louis Pérusse; Irene Pichler; Maria G Pilia; Anneli Pouta; Myriam Rheinberger; Rasmus Ribel-Madsen; Marcus Richards; Kenneth M Rice; Treva K Rice; Carlo Rivolta; Veikko Salomaa; Alan R Sanders; Mark A Sarzynski; Salome Scholtens; Robert A Scott; William R Scott; Sylvain Sebert; Sebanti Sengupta; Bengt Sennblad; Thomas Seufferlein; Angela Silveira; P Eline Slagboom; Jan H Smit; Thomas H Sparsø; Kathleen Stirrups; Ronald P Stolk; Heather M Stringham; Morris A Swertz; Amy J Swift; Ann-Christine Syvänen; Sian-Tsung Tan; Barbara Thorand; Anke Tönjes; Angelo Tremblay; Emmanouil Tsafantakis; Peter J van der Most; Uwe Völker; Marie-Claude Vohl; Judith M Vonk; Melanie Waldenberger; Ryan W Walker; Roman Wennauer; Elisabeth Widén; Gonneke Willemsen; Tom Wilsgaard; Alan F Wright; M Carola Zillikens; Suzanne C van Dijk; Natasja M van Schoor; Folkert W Asselbergs; Paul I W de Bakker; Jacques S Beckmann; John Beilby; David A Bennett; Richard N Bergman; Sven Bergmann; Carsten A Böger; Bernhard O Boehm; Eric Boerwinkle; Dorret I Boomsma; Stefan R Bornstein; Erwin P Bottinger; Claude Bouchard; John C Chambers; Stephen J Chanock; Daniel I Chasman; Francesco Cucca; Daniele Cusi; George Dedoussis; Jeanette Erdmann; Johan G Eriksson; Denis A Evans; Ulf de Faire; Martin Farrall; Luigi Ferrucci; Ian Ford; Lude Franke; Paul W Franks; Philippe Froguel; Ron T Gansevoort; Christian Gieger; Henrik Grönberg; Vilmundur Gudnason; Ulf Gyllensten; Per Hall; Anders Hamsten; Pim van der Harst; Caroline Hayward; Markku Heliövaara; Christian Hengstenberg; Andrew A Hicks; Aroon Hingorani; Albert Hofman; Frank Hu; Heikki V Huikuri; Kristian Hveem; Alan L James; Joanne M Jordan; Antti Jula; Mika Kähönen; Eero Kajantie; Sekar Kathiresan; Lambertus A L M Kiemeney; Mika Kivimaki; Paul B Knekt; Heikki A Koistinen; Jaspal S Kooner; Seppo Koskinen; Johanna Kuusisto; Winfried Maerz; Nicholas G Martin; Markku Laakso; Timo A Lakka; Terho Lehtimäki; Guillaume Lettre; Douglas F Levinson; Lars Lind; Marja-Liisa Lokki; Pekka Mäntyselkä; Mads Melbye; Andres Metspalu; Braxton D Mitchell; Frans L Moll; Jeffrey C Murray; Arthur W Musk; Markku S Nieminen; Inger Njølstad; Claes Ohlsson; Albertine J Oldehinkel; Ben A Oostra; Lyle J Palmer; James S Pankow; Gerard Pasterkamp; Nancy L Pedersen; Oluf Pedersen; Brenda W Penninx; Markus Perola; Annette Peters; Ozren Polašek; Peter P Pramstaller; Bruce M Psaty; Lu Qi; Thomas Quertermous; Olli T Raitakari; Tuomo Rankinen; Rainer Rauramaa; Paul M Ridker; John D Rioux; Fernando Rivadeneira; Jerome I Rotter; Igor Rudan; Hester M den Ruijter; Juha Saltevo; Naveed Sattar; Heribert Schunkert; Peter E H Schwarz; Alan R Shuldiner; Juha Sinisalo; Harold Snieder; Thorkild I A Sørensen; Tim D Spector; Jan A Staessen; Bandinelli Stefania; Unnur Thorsteinsdottir; Michael Stumvoll; Jean-Claude Tardif; Elena Tremoli; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; André L M Verbeek; Sita H Vermeulen; Jorma S Viikari; Veronique Vitart; Henry Völzke; Peter Vollenweider; Gérard Waeber; Mark Walker; Henri Wallaschofski; Nicholas J Wareham; Hugh Watkins; Eleftheria Zeggini; Aravinda Chakravarti; Deborah J Clegg; L Adrienne Cupples; Penny Gordon-Larsen; Cashell E Jaquish; D C Rao; Goncalo R Abecasis; Themistocles L Assimes; Inês Barroso; Sonja I Berndt; Michael Boehnke; Panos Deloukas; Caroline S Fox; Leif C Groop; David J Hunter; Erik Ingelsson; Robert C Kaplan; Mark I McCarthy; Karen L Mohlke; Jeffrey R O'Connell; David Schlessinger; David P Strachan; Kari Stefansson; Cornelia M van Duijn; Joel N Hirschhorn; Cecilia M Lindgren; Iris M Heid; Kari E North; Ingrid B Borecki; Zoltán Kutalik; Ruth J F Loos; DIAGRAM Consortium

doi:10.1371/journal.pgen.1005378

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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

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Peer reviewed

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata, Mary F Feitosa, Su Chu, Jacek Czajkowski, Tõnu Esko, Tove Fall, Tuomas O Kilpeläinen, …

PLoS genetics, Vol.11(10), pp.e1005378-42

01/10/2015

DOI: https://doi.org/10.1371/journal.pgen.1005378

PMCID: PMC4591371

PMID: 26426971

Abstract

Adult

Age Factors

Aged

Body Mass Index

Body Size - genetics

Chromosome Mapping

Female

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Male

Middle Aged

Polymorphism, Single Nucleotide

Sex Characteristics

Waist-Hip Ratio

Whites

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.

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Title: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Creators - without role: Thomas W Winkler - University of Regensburg
Anne E Justice - University of North Carolina at Chapel Hill
Mariaelisa Graff - University of North Carolina at Chapel Hill
Llilda Barata - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Mary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Su Chu - University of Michigan–Ann Arbor
Jacek Czajkowski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Tõnu Esko
Tove Fall
Tuomas O Kilpeläinen
Yingchang Lu
Reedik Mägi
Evelin Mihailov - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia
Tune H Pers
Sina Rüeger
Alexander Teumer
Georg B Ehret
Teresa Ferreira - University of Oxford
Nancy L Heard-Costa
Juha Karjalainen - University Medical Center Groningen
Vasiliki Lagou
Anubha Mahajan - University of Oxford
Michael D Neinast - The University of Texas Southwestern Medical Center
Inga Prokopenko
Jeannette Simino - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Tanya M Teslovich - University of Michigan–Ann Arbor
Rick Jansen - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
Harm-Jan Westra
Charles C White - Boston University
Devin Absher - HudsonAlpha Institute for Biotechnology
Tarunveer S Ahluwalia
Shafqat Ahmad - Skåne University Hospital
Eva Albrecht - Helmholtz Zentrum München
Alexessander Couto Alves - Imperial College London
Jennifer L Bragg-Gresham - University of Michigan–Ann Arbor
Anton J M de Craen - Leiden University Medical Center
Joshua C Bis
Amélie Bonnefond
Gabrielle Boucher - Montreal Heart Institute
Gemma Cadby - University of Western Australia
Yu-Ching Cheng
Charleston W K Chiang - University of California, Los Angeles
Graciela Delgado - Heidelberg
Ayse Demirkan - Erasmus MC
Nicole Dueker - Universiy of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America
Niina Eklund
Gudny Eiriksdottir - Icelandic Heart Association
Joel Eriksson - University of Gothenburg
Bjarke Feenstra - Statens Serum Institut
Krista Fischer - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia
Francesca Frau
Tessel E Galesloot - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands
Frank Geller - Statens Serum Institut
Anuj Goel
Mathias Gorski
Tanja B Grammer - Heidelberg
Stefan Gustafsson
Saskia Haitjema - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands
Jouke-Jan Hottenga - University of Amsterdam
Jennifer E Huffman
Anne U Jackson - University of Michigan–Ann Arbor
Kevin B Jacobs
Åsa Johansson
Marika Kaakinen
Marcus E Kleber - Heidelberg
Jari Lahti
Irene Mateo Leach - University Medical Center Groningen
Benjamin Lehne - Imperial College London
Youfang Liu - University of North Carolina at Chapel Hill
Ken Sin Lo - Montreal Heart Institute
Mattias Lorentzon - University of Gothenburg
Jian'an Luan - University of Cambridge
Pamela A F Madden - Washington University Medical School, St. Louis, Missouri, United States of America
Massimo Mangino - King's College London
Barbara McKnight
Carolina Medina-Gomez
Keri L Monda
May E Montasser - Genomic
Gabriele Müller - Evidence
Martina Müller-Nurasyid
Ilja M Nolte - University Medical Center Groningen
Kalliope Panoutsopoulou - Wellcome Sanger Institute
Laura Pascoe - Newcastle University
Lavinia Paternoster - University of Bristol
Nigel W Rayner
Frida Renström - Skåne University Hospital
Federica Rizzi
Lynda M Rose - Brigham and Women's Hospital
Kathy A Ryan - Genomic
Perttu Salo
Serena Sanna - GeneTiCA
Hubert Scharnagl - Medical University of Graz
Jianxin Shi - National Cancer Institute, Bethesda, Maryland, United States of America
Albert Vernon Smith
Lorraine Southam
Alena Stančáková - University of Eastern Finland
Valgerdur Steinthorsdottir - deCODE Genetics
Rona J Strawbridge
Yun Ju Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Ioanna Tachmazidou - Wellcome Sanger Institute
Toshiko Tanaka - National Institute on Aging
Gudmar Thorleifsson - deCODE Genetics
Stella Trompet
Natalia Pervjakova
Jonathan P Tyrer - University of Cambridge
Liesbeth Vandenput - University of Gothenburg
Sander W van der Laan - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands
Nathalie van der Velde
Jessica van Setten - University Medical Center Utrecht
Jana V van Vliet-Ostaptchouk - University Medical Center Groningen
Niek Verweij - University Medical Center Groningen
Efthymia Vlachopoulou - University of Helsinki
Lindsay L Waite - HudsonAlpha Institute for Biotechnology
Sophie R Wang
Zhaoming Wang
Sarah H Wild - University of Edinburgh
Christina Willenborg
James F Wilson - University of Edinburgh
Andrew Wong - Massachusetts Rehabilitation Commission
Jian Yang - University of Queensland
Loïc Yengo
Laura M Yerges-Armstrong - Genomic
Lei Yu - Rush University Medical Center
Weihua Zhang
Jing Hua Zhao - University of Cambridge
Ehm A Andersson - University of Copenhagen
Stephan J L Bakker - University Medical Center Groningen
Damiano Baldassarre
Karina Banasik - University of Copenhagen
Matteo Barcella - University of Milan
Cristina Barlassina - University of Milan
Claire Bellis
Paola Benaglio
John Blangero - Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
Matthias Blüher
Fabrice Bonnet - University of Rennes
Lori L Bonnycastle - National Human Genome Research Institute
Heather A Boyd - Statens Serum Institut
Marcel Bruinenberg - University Medical Center Groningen
Aron S Buchman - Rush University Medical Center
Harry Campbell - University of Edinburgh
Yii-Der Ida Chen - Harbor–UCLA Medical Center
Peter S Chines - National Human Genome Research Institute
Simone Claudi-Boehm - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany
John Cole
Francis S Collins - National Human Genome Research Institute
Eco J C de Geus
Lisette C P G M de Groot - Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Maria Dimitriou
Jubao Duan
Stefan Enroth
Elodie Eury
Aliki-Eleni Farmaki - Harokopio University of Athens
Nita G Forouhi - University of Cambridge
Nele Friedrich - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
Pablo V Gejman
Bruna Gigante - Karolinska Institutet
Nicola Glorioso - University of Sassari
Alan S Go - Kaiser Permanente Division of Research
Omri Gottesman
Jürgen Gräßler - Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany
Harald Grallert
Niels Grarup - University of Copenhagen
Yu-Mei Gu - KU Leuven
Linda Broer - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Annelies C Ham - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Torben Hansen
Tamara B Harris
Catharina A Hartman - University Medical Center Groningen
Maija Hassinen - Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
Nicholas Hastie - University of Edinburgh
Andrew T Hattersley - University of Exeter
Andrew C Heath - Washington University Medical School, St. Louis, Missouri, United States of America
Anjali K Henders - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia
Dena Hernandez - National Institute on Aging
Hans Hillege - University Medical Center Groningen
Oddgeir Holmen - Norwegian University of Science and Technology
Kees G Hovingh - Academic Medical Center
Jennie Hui
Lise L Husemoen - Glostrup Hospital
Nina Hutri-Kähönen
Pirro G Hysi - King's College London
Thomas Illig
Philip L De Jager
Shapour Jalilzadeh
Torben Jørgensen
J Wouter Jukema
Markus Juonala
Stavroula Kanoni
Maria Karaleftheri - Echinos Medical Centre, Echinos, Greece
Kay Tee Khaw - Addenbrooke's Hospital
Leena Kinnunen - Department of Health, National Institute for Health and Welfare, Helsinki, Finland
Steven J Kittner
Wolfgang Koenig - University of Ulm
Ivana Kolcic - University of Split
Peter Kovacs - IFB Adiposity Diseases
Nikolaj T Krarup - University of Copenhagen
Wolfgang Kratzer - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany
Janine Krüger - Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
Diana Kuh - Massachusetts Rehabilitation Commission
Meena Kumari - Department of Epidemiology and Public Health, UCL, London, United Kingdom
Theodosios Kyriakou
Claudia Langenberg
Lars Lannfelt - Uppsala University
Chiara Lanzani
Vaneet Lotay - University of Calgary
Lenore J Launer - National Institute on Aging
Karin Leander - Karolinska Institutet
Jaana Lindström - Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
Allan Linneberg
Yan-Ping Liu - KU Leuven
Stéphane Lobbens
Robert Luben - Strangeways Research Laboratory Wort's Causeway, Cambridge, United Kingdom
Valeriya Lyssenko
Satu Männistö - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland
Patrik K Magnusson - Karolinska Institutet
Wendy L McArdle - University of Bristol
Cristina Menni - King's College London
Sigrun Merger - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany
Lili Milani - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia
Grant W Montgomery - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia
Andrew P Morris
Narisu Narisu - National Human Genome Research Institute
Mari Nelis - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia
Ken K Ong
Aarno Palotie
Louis Pérusse
Irene Pichler - University of Lübeck
Maria G Pilia - GeneTiCA
Anneli Pouta
Myriam Rheinberger - University Hospital Regensburg
Rasmus Ribel-Madsen - University of Copenhagen
Marcus Richards - Massachusetts Rehabilitation Commission
Kenneth M Rice - University of Washington
Treva K Rice
Carlo Rivolta - University of Lausanne
Veikko Salomaa - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland
Alan R Sanders
Mark A Sarzynski - Pennington Biomedical Research Center
Salome Scholtens - University Medical Center Groningen
Robert A Scott - University of Cambridge
William R Scott
Sylvain Sebert - University of Oulu
Sebanti Sengupta - University of Michigan–Ann Arbor
Bengt Sennblad
Thomas Seufferlein - Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany
Angela Silveira
P Eline Slagboom - Leiden University Medical Center
Jan H Smit - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
Thomas H Sparsø - University of Copenhagen
Kathleen Stirrups
Ronald P Stolk - University Medical Center Groningen
Heather M Stringham - University of Michigan–Ann Arbor
Morris A Swertz - University Medical Center Groningen
Amy J Swift - National Human Genome Research Institute
Ann-Christine Syvänen
Sian-Tsung Tan
Barbara Thorand
Anke Tönjes - University of Leipzig, Department of Medicine, Leipzig, Germany
Angelo Tremblay - Université du Québec
Emmanouil Tsafantakis - Anogia Medical Centre, Anogia, Greece
Peter J van der Most - University Medical Center Groningen
Uwe Völker
Marie-Claude Vohl
Judith M Vonk - University Medical Center Groningen
Melanie Waldenberger
Ryan W Walker
Roman Wennauer - Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany
Elisabeth Widén - University of Helsinki
Gonneke Willemsen - University of Amsterdam
Tom Wilsgaard
Alan F Wright - University of Edinburgh
M Carola Zillikens
Suzanne C van Dijk - Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Natasja M van Schoor
Folkert W Asselbergs
Paul I W de Bakker
Jacques S Beckmann - SIB Swiss Institute of Bioinformatics
John Beilby
David A Bennett - Rush University Medical Center
Richard N Bergman - Cedars-Sinai Medical Center
Sven Bergmann
Carsten A Böger - University Hospital Regensburg
Bernhard O Boehm
Eric Boerwinkle - Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America
Dorret I Boomsma - University of Amsterdam
Stefan R Bornstein - Faculty
Erwin P Bottinger
Claude Bouchard - Pennington Biomedical Research Center
John C Chambers
Stephen J Chanock
Daniel I Chasman
Francesco Cucca
Daniele Cusi
George Dedoussis - Harokopio University of Athens
Jeanette Erdmann
Johan G Eriksson
Denis A Evans - Rush University Medical Center
Ulf de Faire - Karolinska Institutet
Martin Farrall
Luigi Ferrucci - National Institute on Aging
Ian Ford - University of Glasgow
Lude Franke
Paul W Franks
Philippe Froguel
Ron T Gansevoort - University Medical Center Groningen
Christian Gieger
Henrik Grönberg - Karolinska Institutet
Vilmundur Gudnason
Ulf Gyllensten
Per Hall - Karolinska Institutet
Anders Hamsten
Pim van der Harst
Caroline Hayward - University of Edinburgh
Markku Heliövaara - Department of Health, National Institute for Health and Welfare, Helsinki, Finland
Christian Hengstenberg
Andrew A Hicks - University of Lübeck
Aroon Hingorani - University College London
Albert Hofman
Frank Hu
Heikki V Huikuri - Oulu University Hospital
Kristian Hveem - Norwegian University of Science and Technology
Alan L James - Sir Charles Gairdner Hospital
Joanne M Jordan - University of North Carolina at Chapel Hill
Antti Jula - National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland
Mika Kähönen
Eero Kajantie
Sekar Kathiresan
Lambertus A L M Kiemeney
Mika Kivimaki - Department of Epidemiology and Public Health, UCL, London, United Kingdom
Paul B Knekt - National Institute for Health and Welfare, Helsinki, Finland
Heikki A Koistinen
Jaspal S Kooner
Seppo Koskinen - Department of Health, National Institute for Health and Welfare, Helsinki, Finland
Johanna Kuusisto - University of Eastern Finland
Winfried Maerz
Nicholas G Martin - QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia
Markku Laakso - University of Eastern Finland
Timo A Lakka
Terho Lehtimäki
Guillaume Lettre
Douglas F Levinson - Stanford University
Lars Lind - Uppsala University
Marja-Liisa Lokki - University of Helsinki
Pekka Mäntyselkä
Mads Melbye
Andres Metspalu - Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia
Braxton D Mitchell
Frans L Moll - University Medical Center Utrecht
Jeffrey C Murray - University of Iowa
Arthur W Musk - Sir Charles Gairdner Hospital
Markku S Nieminen - HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
Inger Njølstad
Claes Ohlsson - University of Gothenburg
Albertine J Oldehinkel - University of Groningen
Ben A Oostra - Erasmus MC
Lyle J Palmer
James S Pankow - University of Minnesota
Gerard Pasterkamp - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands
Nancy L Pedersen - Karolinska Institutet
Oluf Pedersen - University of Copenhagen
Brenda W Penninx - Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
Markus Perola
Annette Peters
Ozren Polašek
Peter P Pramstaller
Bruce M Psaty
Lu Qi
Thomas Quertermous - Stanford University School of Medicine
Olli T Raitakari
Tuomo Rankinen - Pennington Biomedical Research Center
Rainer Rauramaa
Paul M Ridker
John D Rioux
Fernando Rivadeneira
Jerome I Rotter - Harbor–UCLA Medical Center
Igor Rudan - University of Edinburgh
Hester M den Ruijter - Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands
Juha Saltevo - Department of Medicine, Central Finland Central Hospital, Jyväskylä, Finland
Naveed Sattar - University of Glasgow
Heribert Schunkert
Peter E H Schwarz - Faculty
Alan R Shuldiner
Juha Sinisalo - HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
Harold Snieder - University Medical Center Groningen
Thorkild I A Sørensen
Tim D Spector - King's College London
Jan A Staessen
Bandinelli Stefania - Florence
Unnur Thorsteinsdottir
Michael Stumvoll
Jean-Claude Tardif
Elena Tremoli
Jaakko Tuomilehto
André G Uitterlinden
Matti Uusitupa
André L M Verbeek - Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands
Sita H Vermeulen
Jorma S Viikari - University of Turku
Veronique Vitart - University of Edinburgh
Henry Völzke
Peter Vollenweider - University Hospital of Lausanne
Gérard Waeber - University Hospital of Lausanne
Mark Walker
Henri Wallaschofski
Nicholas J Wareham - University of Cambridge
Hugh Watkins
Eleftheria Zeggini - Wellcome Sanger Institute
Aravinda Chakravarti - Johns Hopkins University School of Medicine
Deborah J Clegg - The University of Texas Southwestern Medical Center
L Adrienne Cupples
Penny Gordon-Larsen
Cashell E Jaquish - National Heart Lung and Blood Institute
D C Rao
Goncalo R Abecasis - University of Michigan–Ann Arbor
Themistocles L Assimes - Stanford University School of Medicine
Inês Barroso
Sonja I Berndt - National Institutes of Health
Michael Boehnke - University of Michigan–Ann Arbor
Panos Deloukas
Caroline S Fox
Leif C Groop
David J Hunter
Erik Ingelsson
Robert C Kaplan - Albert Einstein College of Medicine
Mark I McCarthy
Karen L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
Jeffrey R O'Connell - Genomic
David Schlessinger - National Institute on Aging
David P Strachan - St George's, University of London
Kari Stefansson
Cornelia M van Duijn
Joel N Hirschhorn
Cecilia M Lindgren
Iris M Heid
Kari E North - University of North Carolina at Chapel Hill
Ingrid B Borecki - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Zoltán Kutalik
Ruth J F Loos
DIAGRAM Consortium
Publication Details: PLoS genetics, Vol.11(10), pp.e1005378-42
Grant note: R01 HL045670 / NHLBI NIH HHS R01 DK062370 / NIDDK NIH HHS U01 DK062418 / NIDDK NIH HHS R01 DA012854 / NIDA NIH HHS U01 HL105198 / NHLBI NIH HHS R01 NS045012 / NINDS NIH HHS R01 DK072193 / NIDDK NIH HHS R01 DK091718 / NIDDK NIH HHS U01 HG004402 / NHGRI NIH HHS R01 AA013321 / NIAAA NIH HHS R01 AG030146 / NIA NIH HHS R56 DA012854 / NIDA NIH HHS P60 DK020541 / NIDDK NIH HHS HHSN268200782096C / NHGRI NIH HHS M01 RR016500 / NCRR NIH HHS R56 AG023629 / NIA NIH HHS P30 DK020541 / NIDDK NIH HHS R01 HL103612 / NHLBI NIH HHS MR/K002414/1 / Medical Research Council RC2 MH089995 / NIMH NIH HHS R01 MH059587 / NIMH NIH HHS R01 AA014041 / NIAAA NIH HHS G0601966 / Medical Research Council R01 HL059367 / NHLBI NIH HHS Z01 HG000024 / Intramural NIH HHS MC_U106179472 / Medical Research Council U01 HG004446 / NHGRI NIH HHS MR/K013351/1 / Medical Research Council MC_UU_12015/2 / Medical Research Council MR/N01104X/1 / Medical Research Council N01HC55022 / NHLBI NIH HHS MC_PC_U127561128 / Medical Research Council R01 HL080467 / NHLBI NIH HHS R01 AG008724 / NIA NIH HHS 20308 / Versus Arthritis T32 HL007055 / NHLBI NIH HHS R01 MH059571 / NIMH NIH HHS P30 DK063491 / NIDDK NIH HHS R01 HL087652 / NHLBI NIH HHS R01 HL071981 / NHLBI NIH HHS Wellcome Trust U01 HL080295 / NHLBI NIH HHS R01 HL120393 / NHLBI NIH HHS MC_UU_12015/5 / Medical Research Council N01HC85083 / NHLBI NIH HHS RF1 AG015819 / NIA NIH HHS U01 HG004423 / NHGRI NIH HHS R01 MH060879 / NIMH NIH HHS N01HG65403 / NHGRI NIH HHS R01 HL117078 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS R01 HL043851 / NHLBI NIH HHS 14136 / Cancer Research UK UM1 CA182913 / NCI NIH HHS N01HC55019 / NHLBI NIH HHS MC_U106179471 / Medical Research Council P60 AR030701 / NIAMS NIH HHS G1002319 / Medical Research Council U01 CA098233 / NCI NIH HHS 098395 / Wellcome Trust N01AG12109 / NIA NIH HHS U01 HL072515 / NHLBI NIH HHS HHSN268201200036C / NHLBI NIH HHS R01 MH081802 / NIMH NIH HHS N01HC85082 / NHLBI NIH HHS MC_UU_12019/1 / Medical Research Council R01 AG017917 / NIA NIH HHS U01 HG004438 / NHGRI NIH HHS R01 DK089256 / NIDDK NIH HHS R01 HL086694 / NHLBI NIH HHS R01 DK075787 / NIDDK NIH HHS U01 HL084756 / NHLBI NIH HHS G1001799 / Medical Research Council P30 DK020572 / NIDDK NIH HHS R01 MH059588 / NIMH NIH HHS 098381 / Wellcome Trust RG/13/2/30098 / British Heart Foundation T32 AG000219 / NIA NIH HHS R01 HL087679 / NHLBI NIH HHS G1000143 / Medical Research Council N01HC85079 / NHLBI NIH HHS R01 HL036310 / NHLBI NIH HHS R01 MH081800 / NIMH NIH HHS RL1 MH083268 / NIMH NIH HHS R01 AG013196 / NIA NIH HHS R01 MH059566 / NIMH NIH HHS R01 AA007535 / NIAAA NIH HHS N01HC55018 / NHLBI NIH HHS R01 DK075681 / NIDDK NIH HHS R01 AG028555 / NIA NIH HHS P60 AR049465 / NIAMS NIH HHS U01 HG004436 / NHGRI NIH HHS P2C HD050924 / NICHD NIH HHS UL1 RR025005 / NCRR NIH HHS MC_UU_12015/1 / Medical Research Council U01 MH079470 / NIMH NIH HHS N01HC55015 / NHLBI NIH HHS 20109 / Versus Arthritis R01 AG011101 / NIA NIH HHS U54 RR020278 / NCRR NIH HHS G0000934 / Medical Research Council P30 DK072488 / NIDDK NIH HHS U24 MH068457 / NIMH NIH HHS T32 HG000040 / NHGRI NIH HHS N01HC25195 / NHLBI NIH HHS R01 MH059565 / NIMH NIH HHS N01HC85081 / NHLBI NIH HHS P30 AG010161 / NIA NIH HHS 098017 / Wellcome Trust G0700931 / Medical Research Council RG/10/12/28456 / British Heart Foundation G0401527 / Medical Research Council U01 GM074518 / NIGMS NIH HHS N01HC85086 / NHLBI NIH HHS R01 MH060870 / NIMH NIH HHS N01HC55016 / NHLBI NIH HHS R01 AG015819 / NIA NIH HHS R01 MH061675 / NIMH NIH HHS U01 MH079469 / NIMH NIH HHS R01 HG002651 / NHGRI NIH HHS R01 MH067257 / NIMH NIH HHS U01 NS069208 / NINDS NIH HHS RC2 MH089951 / NIMH NIH HHS R01 MH063706 / NIMH NIH HHS N02HL64278 / NHLBI NIH HHS N01HC85080 / NHLBI NIH HHS R01 MD009164 / NIMHD NIH HHS R01 MH059586 / NIMH NIH HHS U01 HL084729 / NHLBI NIH HHS P30 DK046200 / NIDDK NIH HHS R01 AA013326 / NIAAA NIH HHS N01HC55021 / NHLBI NIH HHS UL1 TR000124 / NCATS NIH HHS R01 AA013320 / NIAAA NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC55222 / NHLBI NIH HHS N01AG12100 / NIA NIH HHS R01 AG010175 / NIA NIH HHS R01 DK093757 / NIDDK NIH HHS G0600705 / Medical Research Council R01 CA047988 / NCI NIH HHS MC_UP_A100_1003 / Medical Research Council R01 HL105756 / NHLBI NIH HHS N01HC55020 / NHLBI NIH HHS U01 DK062370 / NIDDK NIH HHS R01 HL087676 / NHLBI NIH HHS F32 AR059469 / NIAMS NIH HHS T32 HL091823 / NHLBI NIH HHS R01 HL087641 / NHLBI NIH HHS R01 HL087647 / NHLBI NIH HHS R37 AG013196 / NIA NIH HHS
Identifiers: 9939613508331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article