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The NF-kappa B transcription factor c-Rel controls host defense against Citrobacter rodentium
Journal article   Open access  Peer reviewed

The NF-kappa B transcription factor c-Rel controls host defense against Citrobacter rodentium

Maik Luu, Rossana Romero, Jasmin Bazant, Elfadil Abass, Sabrina Hartmann, Hanna Leister, Florence Fischer, Rouzbeh Mahdavi, Carlos Plaza-Sirvent, Ingo Schmitz, …
European journal of immunology, Vol.50(2), pp.292-294
01/02/2020
DOI: https://doi.org/10.1002/eji.201948314
PMID: 31724737

Abstract

Immunology Life Sciences & Biomedicine Science & Technology
Mice lacking CD4(+) T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.
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https://doi.org/10.1002/eji.201948314View
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