Abstract
Depression has been recently one of the most prevalent psychological disorders that affect various age groups. Olanzapine is an anti-depressant which exerts a systematic effect upon body organs in general. Many studies have illustrated the harmful impacts, organic changes, and side effects caused by taking tranquilizers. Many of those studies clearly indicated the liver, which plays a primary role in filtering toxins along with fatty tissues, as being the primary victim thereof. This particular study was conducted on Albino rats which were divided into several groups. The first group consisted of 10 male albino rats, considered as the negative group, which were fed on basal diet. The Second group included 10 male albino rats, considered as the positive group, in which the rats were orally given the drug Zyprexaata with the dose of 6mg/kg body weight/day for 8 weeks through the oral route via a gasfric tube. The third group composed of 10 male albino rats, considered as the treated group, and they were orally given Nigella Sativaata with the dose of 2m1/kg body weight/day for a period of four weeks after being medicated for four weeks via a gasfric tube. At the end of the experimental period, the autopsy of the liver specimens was taken and fixed in formaldehyde based on the standard procedures for the preparation of microscopic examination. The examination of various sections of hepatic tissues revealed pathological and histological changes, where the liver cells appeared deformed in addition to the occurrence of hemostasis, hemorrhages and inflammation of hepatic cells.