Abstract
Any drug can have side effect at a certain dose which limits its use. On the other hand, evidence support the role of herbal medicines in the prevention and cure of several diseases. Thymoquinone (TQ) is a bioactive component found in the volatile oil of Nigella sativa "black seed". Studies have demonstrated the therapeutic and protective activity of TQ against drug toxicities on various body systems which have been attempted to be reviewed in this article.