Abstract
In this study the solubility of beclomethasone-17,21-dipropionate in acetone, methanol, and ethanol as model systems to investigate the supercritical gas antisolvent micronization process was performed over a wide range of temperatures. Beclomethasone-17,21-dipropionate is an inhaled steroid used for the treatment of asthma. Experimental determination of the solubility of beclomethasone-17,21-dipropionate in the three solvents was achieved by employing a gravimetric technique over the temperatures range 24.5-62.5 degrees C. The solubility data were modeled using the group contribution parameters and UNIversal QUAsi-Chemical (UNIQUAC) theory. The binary parameters of the UNIQUAC model were calculated by employing the experimental solubility data. Good predictions of the solubility measurements were achieved using the UNIQUAC model.