The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents

M. M. Ghorab; A. N. Osman; E. Noaman; H. I. Heiba; N. H. Zaher

doi:10.1080/10426500500544238

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The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents

Journal article

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The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents

M. M. Ghorab, A. N. Osman, E. Noaman, H. I. Heiba and N. H. Zaher

Phosphorus, sulfur, and silicon and the related elements, Vol.181(9), pp.1983-1996

01/09/2006

DOI: https://doi.org/10.1080/10426500500544238

Abstract

Anticancer agents

new thiophene and thieno[2,3-d]pyrimidine derivatives

radioprotective

The synthesis of novel thioureido derivatives 3, 8, and 10; biscompounds 7, 9, and 11; and tetracyclic compounds 5, 6, and 16 utilizing 5-isothiocyanato-3-methyl-thiophene-2,4-dicarboxylic acid diethyl ester 2 are reported. The structures of these compounds were confirmed by microanalyses and IR, 1 H NMR, and mass spectroscopy. Preliminary biological studies of some of the synthesized compounds showed promising radioprotective and anticancer activities.

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Title: The Utility of Isothiocyanato Thiophenes in the Synthesis of Thieno[2,3-d]pyrimidine Derivatives as Possible Radioprotective and Anticancer Agents
Creators - without role: M. M. Ghorab - Department of Drug Radiation Research , National Center for Radiation Research and Technology , Nasr City, Cairo, Egypt
A. N. Osman - Cairo University
E. Noaman - Department of Radiation Biology , National Center for Radiation Research and Technology , Nasr City, Cairo, Egypt
H. I. Heiba - Department of Drug Radiation Research , National Center for Radiation Research and Technology , Nasr City, Cairo, Egypt
N. H. Zaher - Department of Drug Radiation Research , National Center for Radiation Research and Technology , Nasr City, Cairo, Egypt
Publication Details: Phosphorus, sulfur, and silicon and the related elements, Vol.181(9), pp.1983-1996
Publisher: Taylor & Francis Group
Identifiers: 9918065908331
Academic Unit: Majmaah University; King Saud University
Language: English
Resource Type: Journal article