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The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer
Journal article   Peer reviewed

The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, …
Chemical communications (Cambridge, England), Vol.56(81), pp.12238-12241
13/10/2020
DOI: https://doi.org/10.1039/d0cc03883k
PMID: 32926011

Abstract

Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Dimerization Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Humans Methane - analogs & derivatives Methane - chemistry Methane - pharmacology Molecular Structure Palladium - chemistry Palladium - pharmacology Structure-Activity Relationship
A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

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