The dynamic genome of Hydra

Jarrod A. Chapman; Ewen F. Kirkness; Oleg Simakov; Steven E. Hampson; Therese Mitros; Thomas Weinmaier; Thomas Rattei; Prakash G. Balasubramanian; Jon Borman; Dana Busam; Kathryn Disbennett; Cynthia Pfannkoch; Nadezhda Sumin; Granger G. Sutton; Lakshmi Devi Viswanathan; Brian Walenz; David M. Goodstein; Uffe Hellsten; Takeshi Kawashima; Simon E. Prochnik; Nicholas H. Putnam; Shengquiang Shu; Bruce Blumberg; Catherine E. Dana; Lydia Gee; Dennis F. Kibler; Lee Law; Dirk Lindgens; Daniel E. Martinez; Jisong Peng; Philip A. Wigge; Bianca Bertulat; Corina Guder; Yukio Nakamura; Suat Ozbek; Hiroshi Watanabe; Konstantin Khalturin; Georg Hemmrich; Andre Franke; Rene Augustin; Sebastian Fraune; Eisuke Hayakawa; Shiho Hayakawa; Mamiko Hirose; Jung Shan Hwang; Kazuho Ikeo; Chiemi Nishimiya-Fujisawa; Atshushi Ogura; Toshio Takahashi; Patrick R. H. Steinmetz; Xiaoming Zhang; Roland Aufschnaiter; Marie-Kristin Eder; Anne-Kathrin Gorny; Willi Salvenmoser; Alysha M. Heimberg; Benjamin M. Wheeler; Kevin J. Peterson; Angelika Boettger; Patrick Tischler; Alexander Wolf; Takashi Gojobori; Karin A. Remington; Robert L. Strausberg; J. Craig Venter; Ulrich Technau; Bert Hobmayer; Thomas C. G. Bosch; Thomas W. Holstein; Toshitaka Fujisawa; Hans R. Bode; Charles N. David; Daniel S. Rokhsar; Robert E. Steele; Joint Genome Institute (JGI)

doi:10.1038/nature08830

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The dynamic genome of Hydra

Jarrod A. Chapman, Ewen F. Kirkness, Oleg Simakov, Steven E. Hampson, Therese Mitros, Thomas Weinmaier, Thomas Rattei, Prakash G. Balasubramanian, Jon Borman, Dana Busam, …

Nature (London), Vol.464(7288), pp.592-596

25/03/2010

DOI: https://doi.org/10.1038/nature08830

PMCID: PMC4479502

PMID: 20228792

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

The freshwater cnidarian Hydra was first described in 1702(1) and has been the object of study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the discovery of asexual reproduction of an animal by budding, the first description of regeneration in an animal, and successful transplantation of tissue between animals(2). Today, Hydra is an important model for studies of axial patterning(3), stem cell biology(4) and regeneration(5). Here we report the genome of Hydra magnipapillata and compare it to the genomes of the anthozoan Nematostella vectensis(6) and other animals. The Hydra genome has been shaped by bursts of transposable element expansion, horizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that parallel simplification of the Hydra life cycle. We also report the sequence of the genome of a novel bacterium stably associated with H. magnipapillata. Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann-Mangold organizer, pluripotency genes and the neuromuscular junction.

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Title: The dynamic genome of Hydra
Creators - without role: Jarrod A. Chapman - Joint Genome Institute
Ewen F. Kirkness - J. Craig Venter Institute
Oleg Simakov - University of California, Berkeley
Steven E. Hampson - University of California, Irvine
Therese Mitros - University of California, Berkeley
Thomas Weinmaier - Technical University of Munich
Thomas Rattei - Technical University of Munich
Prakash G. Balasubramanian - Heidelberg University
Jon Borman - J. Craig Venter Institute
Dana Busam - J. Craig Venter Institute
Kathryn Disbennett - J. Craig Venter Institute
Cynthia Pfannkoch - J. Craig Venter Institute
Nadezhda Sumin - J. Craig Venter Institute
Granger G. Sutton - J. Craig Venter Institute
Lakshmi Devi Viswanathan - J. Craig Venter Institute
Brian Walenz - J. Craig Venter Institute
David M. Goodstein - Joint Genome Institute
Uffe Hellsten - Joint Genome Institute
Takeshi Kawashima - University of California, Berkeley
Simon E. Prochnik - Joint Genome Institute
Nicholas H. Putnam - Joint Genome Institute
Shengquiang Shu - Joint Genome Institute
Bruce Blumberg - University of California, Irvine
Catherine E. Dana - University of California, Irvine
Lydia Gee - University of California, Irvine
Dennis F. Kibler - University of California, Irvine
Lee Law - University of California, Irvine
Dirk Lindgens - University of California, Irvine
Daniel E. Martinez - Pomona College
Jisong Peng - University of California, Irvine
Philip A. Wigge - Salk Institute for Biological Studies
Bianca Bertulat - Heidelberg University
Corina Guder - Heidelberg University
Yukio Nakamura - Heidelberg University
Suat Ozbek - Heidelberg University
Hiroshi Watanabe - Heidelberg University
Konstantin Khalturin - Kiel University
Georg Hemmrich - Kiel University
Andre Franke - Kiel University
Rene Augustin - Kiel University
Sebastian Fraune - Kiel University
Eisuke Hayakawa - National Institute of Genetics
Shiho Hayakawa - National Institute of Genetics
Mamiko Hirose - National Institute of Genetics
Jung Shan Hwang - National Institute of Genetics
Kazuho Ikeo - National Institute of Genetics
Chiemi Nishimiya-Fujisawa - National Institute of Genetics
Atshushi Ogura - National Institute of Genetics
Toshio Takahashi - Suntory Foundation for Life Sciences
Patrick R. H. Steinmetz - University of Vienna
Xiaoming Zhang - University of Kansas Medical Center
Roland Aufschnaiter - Universität Innsbruck
Marie-Kristin Eder - Universität Innsbruck
Anne-Kathrin Gorny - Universität Innsbruck
Willi Salvenmoser - Universität Innsbruck
Alysha M. Heimberg - Dartmouth College
Benjamin M. Wheeler - North Carolina State University
Kevin J. Peterson - Dartmouth College
Angelika Boettger - Univ Munich, Dept Biol 2, D-82152 Planegg Martinsried, Germany
Patrick Tischler - Technical University of Munich
Alexander Wolf - Ludwig-Maximilians-Universität München
Takashi Gojobori - National Institute of Genetics
Karin A. Remington - J. Craig Venter Institute
Robert L. Strausberg - J. Craig Venter Institute
J. Craig Venter - J. Craig Venter Institute
Ulrich Technau - University of Vienna
Bert Hobmayer - Universität Innsbruck
Thomas C. G. Bosch - Kiel University
Thomas W. Holstein - Heidelberg University
Toshitaka Fujisawa - National Institute of Genetics
Hans R. Bode - University of California, Irvine
Charles N. David - Ludwig-Maximilians-Universität München
Daniel S. Rokhsar - Joint Genome Institute
Robert E. Steele - University of California, Irvine
Joint Genome Institute (JGI)
Publication Details: Nature (London), Vol.464(7288), pp.592-596
Publisher: Springer Nature
Number of pages: 5
Grant note: Ministry of Education, Culture, Sports, Science, and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) DEB-0716960 / NSF; National Science Foundation (NSF) TOYOBO Biotechnology Foundation R. Melmon and the Gordon and Betty Moore Foundation P 20734; P 21108 / Austrian Science Fund (FWF) SFB617-A1; SFB488-A12 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) Austrian Science Fund; Austrian Science Fund (FWF) Alexander von Humboldt Foundation Norwegian Research Council; Research Council of Norway FWF P16685; FWF P20734 / Austrian Science Fund; Austrian Science Fund (FWF) IBN-0120591 / National Science Foundation; National Science Foundation (NSF) DE-AC02-05CH11231 / Office of Science of the US Department of Energy; United States Department of Energy (DOE)
Identifiers: 9944900208331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article