Abstract
This study was designed to assess the effect of LS nanoparticles on glucose homeostasis and its role in alleviating the impact of streptozotocin (STZ)-induced diabetes on the testes and sperm production. Four groups (n=10 each) of male albino rats were utilized; the control group, the LS-treated, STZ-induced DM and LS-treated DM groups. Serum glucose, insulin, and testosterone levels were measured and sperm parameters were assessed. Testes were histopathologically examined. LS-treated administration to diabetic rats induced a significant reduction (p<0.001) in blood glucose level and a significant increase (p<0.001) in serum insulin and testosterone. A significant positive correlation (p<0.001) existed between serum testosterone and HOMA beta-cells, insulin, sperm count and sperm. LS-treated diabetic group showed a significant increase in sperm count and motility and a significant reduction (p<0.001) in the percentage of the abnormal sperm. Testes of LS-treated diabetic group showed marked improvement of diabetes-induced histopathological changes.