Abstract
Liver injury was induced by subcutaneous administration of thioacetamide (200 mg/kg/wt) and the plasma level of Zn and Cu along with alanine aminotransferase (Alt) and asparate aminotransferase (Ast) studied. Administration of green tea improved the plasma level of Zn, Cu and Cu/Zn ratio. Thioacetamide induced elevation of Ast in experimental animals, however, green tea administration improved both Ast level and Ast/Alt ratio significantly. Histopathological studies have shown that green tea administration showed improvement in hepatic architecture at the initial stages of the study. The present study shows that one dose of thioacetamide administration resulted in performed liver injury, and supplementation of I green tea has improved plasma level of Zn and Cu as well as Ast, Alt and Ast/Alt ratio.