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The effect of induced liver, kidney and lung lesions on the toxicity of levamisole and diazinon in calves
Journal article   Peer reviewed

The effect of induced liver, kidney and lung lesions on the toxicity of levamisole and diazinon in calves

E B Abdelsalam and E J Ford
Journal of comparative pathology, Vol.97(6), pp.619-627
01/11/1987
PMID: 3443686

Abstract

Animals Carbon Tetrachloride Poisoning - physiopathology Cattle Chemical and Drug Induced Liver Injury Cholinesterases - blood Diazinon - toxicity Insecticides - toxicity Kidney Diseases - chemically induced Kidney Diseases - physiopathology Levamisole - toxicity Liver Diseases - physiopathology Lung Diseases - chemically induced Lung Diseases - physiopathology Mercuric Chloride Tryptophan
Liver damage in calves, produced by the oral administration of the flukecide, carbon tetrachloride, increased the toxic effect of diazinon but not of levamisole, whereas the presence of a renal tubular lesion caused by mercuric chloride enhanced the toxicity of both commonly used anthelmintic compounds. The toxicity of diazinon was increased in calves with a lung lesion caused by oral dosing with tryptophan, an agent implicated in 'fog fever' of cattle.

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