Abstract
Introduction: The impact of non-invasive ventilation on neuromuscular disease (NMD) has become evident over the past two decades due to frequent use of this technique. It allows some patients with non-progressive pathology to almost live a normal life. The purpose of this study is to indicate the impact of NIV and its results in NMD patients.
Objectives: The primary objectives for the study were to find the incidence and outcome of NMD patient on NIV, to determine whether NIV can avoid intubation and Mechanical ventilation and to compare vital signs and arterial blood gas parameters before and after NIV.
Methodology: This retrospective study was conducted during a period from January 2010 to October 2017 in King Abdul-Aziz Medical city (KAMC). The data was collected from Medical Record Department. The collected data got statistically analyzed and results obtained by using SPSS software. A total number of 21 patients admitted in KAMC in adult ICUs, wards, and Emergency room for both males and females with neuromuscular diseases with an age above 18 years old were included. Parameters related to patients and NIV were collected and recorded in an excel sheet and there by SPSS software.
Results: A total of 21 patients enrolled in this study. There were 14 males and 7 females. The minimum age 19 years old and the maximum 81 years old with a mean age of 45. Arterial Blood Gas done Pre and Post NIV and compared using paired't' test. The pre and post pH on NIV was significant with a P value (p: 0.029). The pre and post PaCO2 on NIV with a P value (P: 0.034) and oxygenation in pre and post NIV with a P value (P: 0.008) was also significant.
Conclusion: In this study, since most of the results indicates poor prognosis, it is difficult to say that NIV improve the quality of life. This can be due to the limitations and bias in the study like the heterogeneity of the diseases and bias can be due to the hospital and its policies.