Abstract
A stable amorphous drug with increased shelf life is synthesized by entrapping the double active pharmaceutical ingredient benzalkonium ibuprofenate (antibacterial as well as anti-inflammatory) in Polyvinyle pyrrollidone exceipient using stoichiometric metathesis reaction. The interaction between the drug and the additive were studied with the help of various experimental techniques. FTIR spectroscopy exposed the intermolecular hydrogen bonding between BaIb and PVP. The shelf life of the amorphous binary mixture is predicted with the help of continious XRD taken at regular interval of time. Molecular dynamics were studied with the help of BDS from deep glassy state in a wide frequency range revealed that it’s a good fragile glass former.