The genetic architecture of type 2 diabetes

Christian Fuchsberger; Jason Flannick; Tanya M. Teslovich; Anubha Mahajan; Vineeta Agarwala; Kyle J. Gaulton; Clement Ma; Pierre Fontanillas; Loukas Moutsianas; Davis J. McCarthy; Manuel A. Rivas; John R. B. Perry; Xueling Sim; Thomas W. Blackwell; Neil R. Robertson; N. William Rayner; Pablo Cingolani; Adam E. Locke; Juan Fernandez Tajes; Heather M. Highland; Josee Dupuis; Peter S. Chines; Cecilia M. Lindgren; Christopher Hartl; Anne U. Jackson; Han Chen; Jeroen R. Huyghe; Martijn van de Bunt; Richard D. Pearson; Ashish Kumar; Martina Mueller-Nurasyid; Niels Grarup; Heather M. Stringham; Eric R. Gamazon; Jaehoon Lee; Yuhui Chen; Robert A. Scott; Jennifer E. Below; Peng Chen; Jinyan Huang; Min Jin Go; Michael L. Stitzel; Dorota Pasko; Stephen C. J. Parker; Tibor V. Varga; Todd Green; Nicola L. Beer; Aaron G. Day-Williams; Teresa Ferreira; Tasha Fingerlin; Momoko Horikoshi; Cheng Hu; Iksoo Huh; Mohammad Kamran Ikram; Bong-Jo Kim; Yongkang Kim; Young Jin Kim; Min-Seok Kwon; Juyoung Lee; Selyeong Lee; Keng-Han Lin; Taylor J. Maxwell; Yoshihiko Nagai; Xu Wang; Ryan P. Welch; Joon Yoon; Weihua Zhang; Nir Barzilai; Benjamin F. Voight; Bok-Ghee Han; Christopher P. Jenkinson; Teemu Kuulasmaa; Johanna Kuusisto; Alisa Manning; Maggie C. Y. Ng; Nicholette D. Palmer; Beverley Balkau; Alena Stancakova; Hanna E. Abboud; Heiner Boeing; Vilmantas Giedraitis; Dorairaj Prabhakaran; Omri Gottesman; James Scott; Jason Carey; Phoenix Kwan; George Grant; Joshua D. Smith; Benjamin M. Neale; Shaun Purcell; Adam S. Butterworth; Joanna M. M. Howson; Heung Man Lee; Yingchang Lu; Soo-Heon Kwak; Wei Zhao; John Danesh; Vincent K. L. Lam; Kyong Soo Park; Danish Saleheen; Wing Yee So; Claudia H. T. Tam; Uzma Afzal; David Aguilar; Rector Arya; Tin Aung; Edmund Chan; Carmen Navarro; Ching-Yu Cheng; Domenico Palli; Adolfo Correa; Joanne E. Curran; Denis Rybin; Vidya S. Farook; Sharon P. Fowler; Barry I. Freedman; Michael Griswold; Daniel Esten Hale; Pamela J. Hicks; Chiea-Chuen Khor; Satish Kumar; Benjamin Lehne; Dorothee Thuillier; Wei Yen Lim; Jianjun Liu; Yvonne T. van der Schouw; Marie Loh; Solomon K. Musani; Sobha Puppala; William R. Scott; Loic Yengo; Sian-Tsung Tan; Herman A. Taylor; Farook Thameem; Gregory Wilson; Tien Yin Wong; Pal Rasmus Njolstad; Jonathan C. Levy; Massimo Mangino; Lori L. Bonnycastle; Thomas Schwarzmayr; Joao Fadista; Gabriela L. Surdulescu; Christian Herder; Christopher J. Groves; Thomas Wieland; Jette Bork-Jensen; Ivan Brandslund; Cramer Christensen; Heikki A. Koistinen; Alex S. F. Doney; Leena Kinnunen; Tonu Esko; Andrew J. Farmer; Liisa Hakaste; Dylan Hodgkiss; Jasmina Kravic; Valeriya Lyssenko; Mette Hollensted; Marit E. Jorgensen; Torben Jorgensen; Claes Ladenvall; Johanne Marie Justesen; Annemari Karajamaki; Jennifer Kriebel; Wolfgang Rathmann; Lars Lannfelt; Torsten Lauritzen; Narisu Narisu; Allan Linneberg; Olle Melander; Lili Milani; Matt Neville; Marju Orho-Melander; Lu Qi; Qibin Qi; Michael Roden; Olov Rolandsson; Amy Swift; Anders H. Rosengren; Kathleen Stirrups; Andrew R. Wood; Evelin Mihailov; Christine Blancher; Mauricio O. Carneiro; Jared Maguire; Ryan Poplin; Khalid Shakir; Timothy Fennell; Mark DePristo; Martin Hrabe de Angelis; Panos Deloukas; Anette P. Gjesing; Goo Jun; Peter Nilsson; Jacquelyn Murphy; Robert Onofrio; Barbara Thorand; Torben Hansen; Christa Meisinger; Frank B. Hu; Bo Isomaa; Fredrik Karpe; Liming Liang; Annette Peters; Cornelia Huth; Stephen P. O'Rahilly; Colin N. A. Palmer; Oluf Pedersen; Rainer Rauramaa; Jaakko Tuomilehto; Veikko Salomaa; Richard M. Watanabe; Ann-Christine Syvanen; Richard N. Bergman; Dwaipayan Bharadwaj; Erwin P. Bottinger; Yoon Shin Cho; Giriraj R. Chandak; Juliana C. N. Chan; Kee Seng Chia; Mark J. Daly; Shah B. Ebrahim; Claudia Langenberg; Paul Elliott; Kathleen A. Jablonski; Donna M. Lehman; Weiping Jia; Ronald C. W. Ma; Toni I. Pollin; Manjinder Sandhu; Nikhil Tandon; Philippe Froguel; Ines Barroso; Yik Ying Teo; Eleftheria Zeggini; Ruth J. F. Loos; Kerrin S. Small; Janina S. Ried; Ralph A. DeFronzo; Harald Grallert; Benjamin Glaser; Andres Metspalu; Nicholas J. Wareham; Mark Walker; Eric Banks; Christian Gieger; Erik Ingelsson; Hae Kyung Im; Thomas Illig; Paul W. Franks; Gemma Buck; Joseph Trakalo; David Buck; Inga Prokopenko; Reedik Magi; Lars Lind; Yossi Farjoun; Katharine R. Owen; Anna L. Gloyn; Konstantin Strauch; Tiinamaija Tuomi; Jaspal Singh Kooner; Jong-Young Lee; Taesung Park; Peter Donnelly; Andrew D. Morris; Andrew T. Hattersley; Donald W. Bowden; Francis S. Collins; Gil Atzmon; John C. Chambers; Timothy D. Spector; Markku Laakso; Tim M. Strom; Graeme I. Bell; John Blangero; Ravindranath Duggirala; E. Shyong Tai; Gilean McVean; Craig L. Hanis; James G. Wilson; Mark Seielstad; Timothy M. Frayling; James B. Meigs; Nancy J. Cox; Rob Sladek; Eric S. Lander; Stacey Gabriel; Noel P. Burtt; Karen L. Mohlke; Thomas Meitinger; Leif Groop; Goncalo Abecasis; Jose C. Florez; Laura J. Scott; Andrew P. Morris; Hyun Min Kang; Michael Boehnke; David Altshuler; Mark I. McCarthy; GoT2D Consortium

doi:10.1038/nature18642

Back

The genetic architecture of type 2 diabetes

Journal article

Peer reviewed

The genetic architecture of type 2 diabetes

Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J. McCarthy, …

Nature (London), Vol.536(7614), pp.41-+

04/08/2016

DOI: https://doi.org/10.1038/nature18642

PMCID: PMC5034897

PMID: 27398621

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing in 12,940 individuals from five ancestry groups. To increase statistical power, we expanded the sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes.

Metrics

1 Record Views

See more details

Details

Title: The genetic architecture of type 2 diabetes
Creators - without role: Christian Fuchsberger - University of Michigan–Ann Arbor
Jason Flannick - Broad Institute
Tanya M. Teslovich - University of Michigan–Ann Arbor
Anubha Mahajan - Wellcome Centre for Human Genetics
Vineeta Agarwala - Broad Institute
Kyle J. Gaulton - Wellcome Centre for Human Genetics
Clement Ma - University of Michigan–Ann Arbor
Pierre Fontanillas - Broad Institute
Loukas Moutsianas - Wellcome Centre for Human Genetics
Davis J. McCarthy - Wellcome Centre for Human Genetics
Manuel A. Rivas - Wellcome Centre for Human Genetics
John R. B. Perry - University of Oxford
Xueling Sim - Statistical Research
Thomas W. Blackwell - University of Michigan–Ann Arbor
Neil R. Robertson - Wellcome Centre for Human Genetics
N. William Rayner - University of Oxford
Pablo Cingolani - McGill University
Adam E. Locke - Statistical Research
Juan Fernandez Tajes - Wellcome Centre for Human Genetics
Heather M. Highland - The University of Texas Health Science Center at Houston
Josee Dupuis - National Heart Lung and Blood Institute
Peter S. Chines - National Institutes of Health
Cecilia M. Lindgren - Broad Institute
Christopher Hartl - Broad Institute
Anne U. Jackson - University of Michigan–Ann Arbor
Han Chen - Boston University
Jeroen R. Huyghe - Statistical Research
Martijn van de Bunt - Wellcome Centre for Human Genetics
Richard D. Pearson - Wellcome Centre for Human Genetics
Ashish Kumar - Wellcome Centre for Human Genetics
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Niels Grarup - Novo Nordisk Foundation
Heather M. Stringham - University of Michigan–Ann Arbor
Eric R. Gamazon - University of Chicago
Jaehoon Lee - Seoul Natl Univ, Dept Stat, Seoul, South Korea
Yuhui Chen - University of Oxford
Robert A. Scott - MRC Epidemiology Unit
Jennifer E. Below - The University of Texas Health Science Center at Houston
Peng Chen - National University Health System
Jinyan Huang - Supreme Council Of Health
Min Jin Go - Korea National Institute of Health
Michael L. Stitzel - Jackson Laboratory
Dorota Pasko - University of Exeter
Stephen C. J. Parker - University of Michigan–Ann Arbor
Tibor V. Varga - Lund University
Todd Green - Broad Institute
Nicola L. Beer - Oxford Centre for Diabetes, Endocrinology and Metabolism
Aaron G. Day-Williams - Wellcome Sanger Institute
Teresa Ferreira - Wellcome Centre for Human Genetics
Tasha Fingerlin - Colorado School of Public Health
Momoko Horikoshi - University of Oxford
Cheng Hu - Shanghai Sixth People's Hospital
Iksoo Huh - Seoul National University
Mohammad Kamran Ikram - Singapore National Eye Center
Bong-Jo Kim - Korea National Institute of Health
Yongkang Kim - Seoul National University
Young Jin Kim - Korea National Institute of Health
Min-Seok Kwon - Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul, South Korea
Juyoung Lee - Korea National Institute of Health
Selyeong Lee - Seoul National University
Keng-Han Lin - Statistical Research
Taylor J. Maxwell - The University of Texas Health Science Center at Houston
Yoshihiko Nagai - McGill University and Génome Québec Innovation Centre
Xu Wang - National University Health System
Ryan P. Welch - Statistical Research
Joon Yoon - Seoul National University
Weihua Zhang - Ealing Hospital
Nir Barzilai - Albert Einstein College of Medicine
Benjamin F. Voight - Translational Therapeutics
Bok-Ghee Han - Korea National Institute of Health
Christopher P. Jenkinson - South Texas Veterans Health Care System
Teemu Kuulasmaa - University of Eastern Finland
Johanna Kuusisto - Kuopio University Hospital
Alisa Manning - Broad Institute
Maggie C. Y. Ng - Wake Forest University
Nicholette D. Palmer - Wake Forest University
Beverley Balkau - Centre de recherche en Epidémiologie et Santé des Populations
Alena Stancakova - University of Eastern Finland
Hanna E. Abboud - The University of Texas Health Science Center at San Antonio
Heiner Boeing - German Institute of Human Nutrition
Vilmantas Giedraitis - Uppsala University
Dorairaj Prabhakaran - Centre for Chronic Disease Control
Omri Gottesman - Icahn School of Medicine at Mount Sinai
James Scott - Imperial College London
Jason Carey - Broad Institute
Phoenix Kwan - University of Michigan–Ann Arbor
George Grant - Broad Institute
Joshua D. Smith - University of Washington
Benjamin M. Neale - Broad Institute
Shaun Purcell - Broad Institute
Adam S. Butterworth - University of Cambridge
Joanna M. M. Howson - University of Cambridge
Heung Man Lee - Chinese University of Hong Kong
Yingchang Lu - Icahn School of Medicine at Mount Sinai
Soo-Heon Kwak - Seoul National University
Wei Zhao - University of Pennsylvania
John Danesh - Wellcome Sanger Institute
Vincent K. L. Lam - Chinese University of Hong Kong
Kyong Soo Park - Seoul National University
Danish Saleheen - University of Pennsylvania
Wing Yee So - Chinese University of Hong Kong
Claudia H. T. Tam - Chinese University of Hong Kong
Uzma Afzal - University of London
David Aguilar - College Station Medical Center
Rector Arya - Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA
Tin Aung - Singapore Eye Research Institute
Edmund Chan - Supreme Council Of Health
Carmen Navarro - IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain
Ching-Yu Cheng - Supreme Council Of Health
Domenico Palli - Florence
Adolfo Correa - University of Mississippi
Joanne E. Curran - The University of Texas Rio Grande Valley
Denis Rybin - Boston University
Vidya S. Farook - Texas Biomedical Research Institute
Sharon P. Fowler - College Station Medical Center
Barry I. Freedman - Supreme Council Of Health
Michael Griswold - University of Mississippi
Daniel Esten Hale - Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA
Pamela J. Hicks - Supreme Council Of Health
Chiea-Chuen Khor - Supreme Council Of Health
Satish Kumar - The University of Texas Rio Grande Valley
Benjamin Lehne - University of London
Dorothee Thuillier - University of Lille
Wei Yen Lim - Supreme Council Of Health
Jianjun Liu - Supreme Council Of Health
Yvonne T. van der Schouw - College Station Medical Center
Marie Loh - University of London
Solomon K. Musani - University of Mississippi
Sobha Puppala - Texas Biomedical Research Institute
William R. Scott - University of London
Loic Yengo - Univ Lille, Lille Pasteur Inst, CNRS UMR8199, Lille, France
Sian-Tsung Tan - Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England
Herman A. Taylor - University of Mississippi
Farook Thameem - College Station Medical Center
Gregory Wilson - Jackson State University
Tien Yin Wong - Singapore Eye Research Institute
Pal Rasmus Njolstad - University of Bergen
Jonathan C. Levy - University of Oxford
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Lori L. Bonnycastle - College Station Medical Center
Thomas Schwarzmayr - Helmholtz Zentrum München
Joao Fadista - Lund University
Gabriela L. Surdulescu - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Christian Herder - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Christopher J. Groves - University of Oxford
Thomas Wieland - Helmholtz Zentrum München
Jette Bork-Jensen - University of Copenhagen
Ivan Brandslund - University of Southern Denmark
Cramer Christensen - College Station Medical Center
Heikki A. Koistinen - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Alex S. F. Doney - Supreme Council Of Health
Leena Kinnunen - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Tonu Esko - Broad Institute
Andrew J. Farmer - University of Oxford
Liisa Hakaste - University of Helsinki
Dylan Hodgkiss - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Jasmina Kravic - Lund University
Valeriya Lyssenko - Lund University
Mette Hollensted - University of Copenhagen
Marit E. Jorgensen - Steno Diabet Ctr, Gentofte, Denmark
Torben Jorgensen - Capital University
Claes Ladenvall - Lund University
Johanne Marie Justesen - University of Copenhagen
Annemari Karajamaki - Vaasa Cent Hosp, Dept Primary Hlth Care, Vaasa, Finland
Jennifer Kriebel - German Ctr Diabet Res DZD, Neuherberg, Germany
Wolfgang Rathmann - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Biometr & Epidemiol, Dusseldorf, Germany
Lars Lannfelt - Uppsala University
Torsten Lauritzen - Aarhus University
Narisu Narisu - College Station Medical Center
Allan Linneberg - Capital University
Olle Melander - Lund University
Lili Milani - University of Tartu
Matt Neville - University of Oxford
Marju Orho-Melander - Lund University
Lu Qi - Supreme Council Of Health
Qibin Qi - Supreme Council Of Health
Michael Roden - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Olov Rolandsson - Umeå University
Amy Swift - College Station Medical Center
Anders H. Rosengren - Lund University
Kathleen Stirrups - Wellcome Sanger Institute
Andrew R. Wood - University of Exeter
Evelin Mihailov - University of Tartu
Christine Blancher - University of Oxford
Mauricio O. Carneiro - Broad Institute
Jared Maguire - Broad Institute
Ryan Poplin - Broad Institute
Khalid Shakir - Broad Institute
Timothy Fennell - Broad Institute
Mark DePristo - Broad Institute
Martin Hrabe de Angelis - German Ctr Diabet Res DZD, Neuherberg, Germany
Panos Deloukas - Queen Mary University of London
Anette P. Gjesing - University of Copenhagen
Goo Jun - Biostat
Peter Nilsson - Lund University
Jacquelyn Murphy - Broad Institute
Robert Onofrio - Broad Institute
Barbara Thorand - German Ctr Diabet Res DZD, Neuherberg, Germany
Torben Hansen - University of Copenhagen
Christa Meisinger - German Ctr Diabet Res DZD, Neuherberg, Germany
Frank B. Hu - Supreme Council Of Health
Bo Isomaa - Folkhalsan Res Ctr, Helsinki, Finland
Fredrik Karpe - University of Oxford
Liming Liang - Biostat
Annette Peters - Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany
Cornelia Huth - German Ctr Diabet Res DZD, Neuherberg, Germany
Stephen P. O'Rahilly - University of Cambridge
Colin N. A. Palmer - University of Dundee
Oluf Pedersen - University of Copenhagen
Rainer Rauramaa - College Station Medical Center
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Veikko Salomaa - Natl Inst Hlth & Welf, Helsinki, Finland
Richard M. Watanabe - Supreme Council Of Health
Ann-Christine Syvanen - Uppsala University
Richard N. Bergman - Cedars Sinai Diabet & Obes Res Inst, Los Angeles, CA USA
Dwaipayan Bharadwaj - Institute of Genomics and Integrative Biology
Erwin P. Bottinger - Supreme Council Of Health
Yoon Shin Cho - Hallym University
Giriraj R. Chandak - CSIR Ctr Cellular & Mol Biol, Hyderabad, Telangana, India
Juliana C. N. Chan - Chinese University of Hong Kong
Kee Seng Chia - Supreme Council Of Health
Mark J. Daly - College Station Medical Center
Shah B. Ebrahim - Ctr Chron Dis Control, New Delhi, India
Claudia Langenberg - University of Cambridge
Paul Elliott - University of London
Kathleen A. Jablonski - George Washington University
Donna M. Lehman - College Station Medical Center
Weiping Jia - Shanghai Jiao Tong University
Ronald C. W. Ma - Chinese University of Hong Kong
Toni I. Pollin - Supreme Council Of Health
Manjinder Sandhu - Wellcome Sanger Institute
Nikhil Tandon - College Station Medical Center
Philippe Froguel - University of Lille
Ines Barroso - Wellcome Sanger Institute
Yik Ying Teo - Supreme Council Of Health
Eleftheria Zeggini - Wellcome Sanger Institute
Ruth J. F. Loos - Supreme Council Of Health
Kerrin S. Small - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Janina S. Ried - Helmholtz Zentrum München
Ralph A. DeFronzo - College Station Medical Center
Harald Grallert - German Ctr Diabet Res DZD, Neuherberg, Germany
Benjamin Glaser - Hadassah
Andres Metspalu - University of Tartu
Nicholas J. Wareham - University of Cambridge
Mark Walker - Newcastle University
Eric Banks - Broad Institute
Christian Gieger - Helmholtz Zentrum München
Erik Ingelsson - University of Oxford
Hae Kyung Im - University of Chicago
Thomas Illig - Helmholtz Zentrum München
Paul W. Franks - Lund University
Gemma Buck - University of Oxford
Joseph Trakalo - University of Oxford
David Buck - University of Oxford
Inga Prokopenko - University of Oxford
Reedik Magi - University of Tartu
Lars Lind - Uppsala University
Yossi Farjoun - Broad Institute
Katharine R. Owen - University of Oxford
Anna L. Gloyn - University of Oxford
Konstantin Strauch - Helmholtz Zentrum München
Tiinamaija Tuomi - University of Helsinki
Jaspal Singh Kooner - Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England
Jong-Young Lee - Korea Natl Inst Hlth, Ctr Genome Sci, Cheongju, Chungcheongbuk, South Korea
Taesung Park - Seoul Natl Univ, Dept Stat, Seoul, South Korea
Peter Donnelly - University of Oxford
Andrew D. Morris - Supreme Council Of Health
Andrew T. Hattersley - University of Exeter
Donald W. Bowden - Supreme Council Of Health
Francis S. Collins - College Station Medical Center
Gil Atzmon - Albert Einstein College of Medicine
John C. Chambers - University of London
Timothy D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Markku Laakso - University of Eastern Finland
Tim M. Strom - Helmholtz Zentrum München
Graeme I. Bell - University of Chicago
John Blangero - The University of Texas Rio Grande Valley
Ravindranath Duggirala - Texas Biomedical Research Institute
E. Shyong Tai - Supreme Council Of Health
Gilean McVean - University of Oxford
Craig L. Hanis - Supreme Council Of Health
James G. Wilson - University of Mississippi
Mark Seielstad - College Station Medical Center
Timothy M. Frayling - University of Exeter
James B. Meigs - College Station Medical Center
Nancy J. Cox - University of Chicago
Rob Sladek - McGill University
Eric S. Lander - Broad Institute
Stacey Gabriel - Broad Institute
Noel P. Burtt - Broad Institute
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Thomas Meitinger - Helmholtz Zentrum München
Leif Groop - Lund University
Goncalo Abecasis - Biostat
Jose C. Florez - Broad Institute
Laura J. Scott - Biostat
Andrew P. Morris - University of Oxford
Hyun Min Kang - Biostat
Michael Boehnke - Biostat
David Altshuler - Broad Institute
Mark I. McCarthy - University of Oxford
GoT2D Consortium
Publication Details: Nature (London), Vol.536(7614), pp.41-+
Publisher: Springer Nature
Number of pages: 29
Grant note: G0601261; MC_UU_12015/1; MR/L01341X/1; MC_UU_12012/5; MR/K002414/1; G0601966; G0800270; G0900747-91070; G0700931 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission ACF-2009-18-005 / National Institute for Health Research; National Institute for Health Research (NIHR) R01AG042188 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01EB015611 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) U01HG005773; U54 HG003067; T32 HG000040; R56 HG000376; U01 HG005773; R01 HG000376; U54HG003067 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) U54 MD007588 / NIMHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) MC_U106179472 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) RG/14/5/30893; SP/04/002; SP/09/002 / British Heart Foundation MC_U106179472 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 098381; 084723; 090532; 090367; 064890; 086596; 083948; 098051; 100956; 092447; 095101; 085475; 098017; 095552 / Wellcome Trust; European Commission R01MH090937 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) CIHR; Canadian Institutes of Health Research (CIHR) NNF12OC1016167 / Novo Nordisk Fonden; Novo Nordisk Foundation R01HL102830 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K12CA139160 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) S10OD018522 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DK062370; R01 DK101478; DK085524; DK072193; R01 DK073541; R01 DK066358; K24DK080140; RC2 DK088389; P30DK020595; U01 DK085524; K24 DK080140; R01DK098032; U01 DK085526; RC2DK088389; R00DK092251; U01 DK085584; DK085584; DK085545; U01 DK078616; DK088389; DK085526; R00 DK092251; 1RC2DK088389; R00 DK099240; DK098032; U01 DK062370; DK093757; U01DK085501; P60DK20595; K24 DK110550; DK085501; P30 DK020572; U01 DK085501; R01DK073541; R01 DK093757; RC2-DK088389; R01 DK072193; P30 DK020595; P60 DK020595; R01 DK106236; U01 DK085545; R01DK066358; R01 DK098032; U01DK085526 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U54MD007588 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) T32GM007753 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01 MH090937; R01MH090937; R01 MH101820; R01MH101820 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) P60DK020595 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) HHSN268201300048C; HHSN268201300049C; HHSN268201300047C; R01 HL102830; HHSN268201300046C; R01HL102830; HHSN268201300050C; T32 HL007055 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K12CA139160 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32 GM007753; T32GM007753 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30AG038072; P01 AG027734; 1R01AG042188; R01 AG046949; R01AG046949; R01 AG042188; P30 AG038072; P01AG027734 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01 EB015611 / NIBIB NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) S10 OD018522 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ZIAHG000024 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
Identifiers: 9939282108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article