The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Georg B. Ehret; Teresa Ferreira; Daniel I. Chasman; Anne U. Jackson; Ellen M. Schmidt; Toby Johnson; Gudmar Thorleifsson; Jian'an Luan; Louise A. Donnelly; Stavroula Kanoni; Ann -Kristin Petersen; Vasyl Pihurl; Rona J. Strawbridge; Dmitry Shungin; Maria F. Hughes; Osorio Meirelles; Marika Kaakinen; Nabila Bouatia-Naji; Kati Kristiansson; Sonia Shah; Marcus E. Kleber; Xiuqing Guo; Leo-Pekka Lyytikainen; Cristiano Fava; Nidas Eriksson; Ilja M. Nolte; Patrik K. Magnusson; Elias L. Salfati; Loukianos S. Rallidis; Elizabeth Theusch; Andrew J. P. Smith; Lasse Folkersen; Kate Witkowska; Tune H. Pers; Roby Joehanes; Stuart K. Kim; Lazaros Lataniotis; Rick Jansen; Andrew D. Johnson; Helen Warren; Young Jin Kim; Wei Zhao; Ying Wu; Bamidele O. Tayo; Murielle Bochud; Devin Absher; Linda S. Adair; Najaf Amin; Dan E. Arkingl; Tomas Axelsson; Damian Baldassarre; Beverley Balkau; Stefania Bandinelli; Michael R. Barnes; Ines Barroso; Stephen Bevan; Joshua C. Bis; Gyda Bjornsdottir; Michael Boehnke; Eric Boerwinkle; Lori L. Bonnycastle; Dorret I. Boomsma; Stefan R. Bornstein; Morris J. Brown; Michel Burnier; Claudia P. Cabrera; John C. Chambers; I-Shou Chang; Ching-Yu Cheng; Peter S. Chines; Ren-Hua Chung; Francis S. Collins; John M. Connell; Angela Doring; Jean Dallongeville; John Danesh; Ulf de Faire; Graciela Delgado; Anna F. Dominiczak; Alex S. F. Doney; Fotios Drenos; Sarah Edkins; John D. Eicher; Roberto Elosua; Stefan Enroth; Jeanette Erdmann; Per Eriksson; Tonu Esko; Evangelos Evangelou; Alun Evans; Tove Fai; Martin Farra; Janine F. Felixl; Jean Ferrieres; Luigi Ferrucci; Myriam Fornage; Terrence Forrester; Nora Franceschinil; Oscar H. Franco; Anders Franco-Cereceda; Ross M. Fraser; Santhi K. Ganesh; He Gao; Karl Gertow; Francesco Gianfagna; Bruna Gigante; Franco Giulianini; Anuj Goe; Alison H. Goodall; Mark Goodarzi; Mathias Gorski; Jurgen Grassler; Christopher J. Groves; Vilmundur Gudnason; Ulf Gyllensten; Goran Hallmans; Anna-Liisa Hartikainen; Maija Hassinen; Aki S. Havulinna; Caroline Hayward; Serge Hercberg; Karl-Heinz Herzig; Andrew A. Hicks; Aroon D. Hingorani; Joel N. Hirschhorn; Albert Hofmanl; Jostein Holmen; Oddgeir Lingaas Holmen; Jouke-Jan Hottenga; Phil Howard; Chao A. Hsiung; Steven C. Hunt; M. Arfan Ikram; Thomas Illig; Carlos Iribarren; Richard A. Jensen; Mika Kahonen; Hyun Min Kang; Sekar Kathiresan; Brendan J. Keating; Kay-Tee Khaw; Yun Kyoung Kim; Eric Kim; Mika Kivimaki; Norman Klopp; Genovefa Kolovou; Pirjo Komulainen; Jaspal S. Kooner; Gulum Kosova; Ronald M. Krauss; Diana Kuh; Zoltan Kutalik; Johanna Kuusisto; Kirsti Kvaloy; Timo A. Lakka; Nanette R. Lee; I-Te Lee; Wen-Jane Lee; Daniel Levy; Xiaohui Li; Kae-Woei Liang; Honghuang Lin; Li Lin; Jaana Lindstrom; Stephane Lobbens; Satu Mannisto; Gabriele Muller; Martina Muller-Nurasyid; Francois Mach; Hugh S. Markus; Eirini Marouli; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Cristina Menni; Andres Metspalu; Vladan Mijatovic; Leena Moilanen; May E. Montasser; Andrew D. Morris; Alanna C. Morrison; Antonella Mulas; Ramaiah Nagaraja; Narisu Narisu; Kjell Nikus; Christopher J. O'Donnell; Paul F. O'Reilly; Ken K. Ong; Fred Paccaud; Cameron D. Palmer; Afshin Parsa; Nancy L. Pedersen; Brenda W. Penninx; Markus Perola; Annette Peters; Neil Poulter; Peter P. Pramstaller; Bruce M. Psaty; Thomas Quertermous; Dabeeru C. Rao; Asif Rasheed; N. William Rayner; Frida Renstrom; Rainer Rettig; Kenneth M. Rice; Robert Roberts; Lynda M. Rose; Jacques Rossouw; Nilesh J. Samani; Serena Sanna; Jouko Saramies; Heribert Schunkert; Sylvain Sebert; Wayne H-H Sheu; Young-Ah Shin; Xueling Sim; Johannes H. Smit; Albert V. Smith; Maria X. Sosa; Tim D. Spector; Alena Stancakova; Alice V. Stanton; Kathleen E. Stirrups; Heather M. Stringham; Johan Sundstrom; Amy J. Swift; Ann-Christine Syvanen; E-Shyong Tai; Toshiko Tanaka; Kirill V. Tarasov; Alexander Teumer; Unnur Thorsteinsdottir; Martin D. Tobin; Elena Tremoli; Andre G. Uitterlinden; Matti Uusitupa; Ahmad Vaez; Dhananjay Vaidya; Cornelia M. van Duijn; Erik P. A. van Iperen; Ramachandran S. Vasan; Germaine C. Verwoert; Jarmo Virtamo; Veronique Vitart; Benjamin F. Voight; Peter Vollenweider; Aline Wagner; Louise V. Wain; Nicholas J. Wareham; Hugh Watldns; Alan B. Weder; Harm Jan Westra; Rainford Wilks; Tom Wilsgaard; James F. Wilson; Tien Y. Wong; Tsun-Po Yang; Jie Yao; Loic Yengo; Weihua Zhang; Jing Hua Zhao; Xiaofeng Zhu; Pascal Bovet; Richard S. Cooper; Karen L. Mohlke; Danish Saleheen; Jong-Young Lee; Paul Elliott; Hinco J. Gierman; Cristen J. Willer; Lude Franke; G. Kees Hovingh; Kent D. Taylor; George Dedoussis; Peter Sever; Andrew Wong; Lars Lind; Themistocles L. Assimes; Inger Njolstad; Peter E. H. Schwarz; Claudia Langenberg; Harold Snieder; Mark J. Caulfield; E. Melander; Markku Laakso; Juha Saltevo; Rainer Rauramaa; Jaakko Tuomilehto; Erik Ingelsson; Terho Lehtimaki; Kristian Hveem; Walter Palmas; Winfried Marz; Meena Kumar; Veikko Salomaa; Yii-Der I. Chen; Jerome I. Rotter; Philippe Froguel; Marjo-Riitta Jarvelin; Edward G. Lakatta; Kari Kuulasmaa; Paul W. Franks; Anders Hamsten; H-Erich Wichmann; Colin N. A. Palmer; Kari Stefansson; Paul M. Ridker; Ruth J. F. Loos; Aravinda Chalcravarti; Panos Deloukas; Andrew P. Morris; Christopher Newton-Cheh; Patricia B. Munroe; CHARGE-HF Consortium

doi:10.1038/ng.3667

Back

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Journal article

Peer reviewed

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Georg B. Ehret, Teresa Ferreira, Daniel I. Chasman, Anne U. Jackson, Ellen M. Schmidt, Toby Johnson, Gudmar Thorleifsson, Jian'an Luan, Louise A. Donnelly, Stavroula Kanoni, …

Nature genetics, Vol.48(10), pp.1171-1184

01/10/2016

DOI: https://doi.org/10.1038/ng.3667

PMID: 27618452

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.

Metrics

1 Record Views

See more details

Details

Title: The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Creators - without role: Georg B. Ehret - Johns Hopkins University
Teresa Ferreira - University of Oxford
Daniel I. Chasman - Brigham and Women's Hospital
Anne U. Jackson - Biostat
Ellen M. Schmidt - College Station Medical Center
Toby Johnson - Queen Mary University of London
Gudmar Thorleifsson - Amgen
Jian'an Luan - University of Cambridge
Louise A. Donnelly - University of Dundee
Stavroula Kanoni - Queen Mary University of London
Ann -Kristin Petersen - Helmholtz Zentrum München
Vasyl Pihurl - Johns Hopkins University
Rona J. Strawbridge - Karolinska Institutet
Dmitry Shungin - Umeå University
Maria F. Hughes - Queens University
Osorio Meirelles - NIA, Genet Lab, Intramural Res Program, US Natl Inst Hlth, Baltimore, MD 21224 USA
Marika Kaakinen - Supreme Council Of Health
Nabila Bouatia-Naji - Inserm
Kati Kristiansson - Natl Inst Hlth & Welf, Helsinki, Finland
Sonia Shah - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Marcus E. Kleber - Heidelberg University
Xiuqing Guo - Biomed Research Institute
Leo-Pekka Lyytikainen - Fimlab
Cristiano Fava - Lund University
Nidas Eriksson - Uppsala University
Ilja M. Nolte - University of Groningen
Patrik K. Magnusson - Karolinska Institutet
Elias L. Salfati - Stanford University
Loukianos S. Rallidis - National and Kapodistrian University of Athens
Elizabeth Theusch - Childrens Hosp Oakland Res Inst, Oakland, CA USA
Andrew J. P. Smith - UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England
Lasse Folkersen - Karolinska Institutet
Kate Witkowska - Queen Mary University of London
Tune H. Pers - Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
Roby Joehanes - Framingham Heart Study
Stuart K. Kim - Stanford University
Lazaros Lataniotis - Queen Mary University of London
Rick Jansen - University of Amsterdam
Andrew D. Johnson - Framingham Heart Study
Helen Warren - Queen Mary University of London
Young Jin Kim - Natl Inst Hlth, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Chungcheongbuk Do, South Korea
Wei Zhao - College Station Medical Center
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Bamidele O. Tayo - Loyola University Chicago
Murielle Bochud - College Station Medical Center
Devin Absher - HudsonAlpha Inst Biotechnol, Huntsville, AL USA
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC USA
Najaf Amin - Erasmus MC
Dan E. Arkingl - Johns Hopkins University
Tomas Axelsson - Uppsala University
Damian Baldassarre - University of Milan
Beverley Balkau - Université Paris Cité
Stefania Bandinelli - Florence
Michael R. Barnes - Queen Mary University of London
Ines Barroso - Wellcome Sanger Institute
Stephen Bevan - Lincoln University
Joshua C. Bis - University of Washington
Gyda Bjornsdottir - Amgen
Michael Boehnke - Biostat
Eric Boerwinkle - Supreme Council Of Health
Lori L. Bonnycastle - College Station Medical Center
Dorret I. Boomsma - University of Amsterdam
Stefan R. Bornstein - College Station Medical Center
Morris J. Brown - Queen Mary University of London
Michel Burnier - CHU Vaudois, Nephrol, Lausanne, Switzerland
Claudia P. Cabrera - Queen Mary University of London
John C. Chambers - Supreme Council Of Health
I-Shou Chang - Natl Inst Canc Res, Natl Hlth Res Inst, Zhunan Town, Taiwan
Ching-Yu Cheng - Singapore Eye Research Institute
Peter S. Chines - College Station Medical Center
Ren-Hua Chung - Biostat
Francis S. Collins - College Station Medical Center
John M. Connell - University of Dundee
Angela Doring - Helmholtz Zentrum München
Jean Dallongeville - University of Lille
John Danesh - Wellcome Sanger Institute
Ulf de Faire - Karolinska Institutet
Graciela Delgado - Heidelberg University
Anna F. Dominiczak - University of Glasgow
Alex S. F. Doney - University of Dundee
Fotios Drenos - UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England
Sarah Edkins - Wellcome Sanger Institute
John D. Eicher - Framingham Heart Study
Roberto Elosua - College Station Medical Center
Stefan Enroth - Uppsala University
Jeanette Erdmann - University of Lübeck
Per Eriksson - Karolinska Institutet
Tonu Esko - Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
Evangelos Evangelou - Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
Alun Evans - Queens University
Tove Fai - Uppsala University
Martin Farra - University of Oxford
Janine F. Felixl - Erasmus MC
Jean Ferrieres - Supreme Council Of Health
Luigi Ferrucci - NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA
Myriam Fornage - College Station Medical Center
Terrence Forrester - Univ West Indies, Trop Metab Res Unit, Res Inst Trop Med, Kingston, Jamaica
Nora Franceschinil - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
Oscar H. Franco - Erasmus MC
Anders Franco-Cereceda - Karolinska Institutet
Ross M. Fraser - University of Edinburgh
Santhi K. Ganesh - Supreme Council Of Health
He Gao - Supreme Council Of Health
Karl Gertow - Karolinska Institutet
Francesco Gianfagna - University of Insubria
Bruna Gigante - Karolinska Institutet
Franco Giulianini - Brigham and Women's Hospital
Anuj Goe - University of Oxford
Alison H. Goodall - University of Leicester
Mark Goodarzi - College Station Medical Center
Mathias Gorski - University of Regensburg
Jurgen Grassler - College Station Medical Center
Christopher J. Groves - University of Oxford
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Ulf Gyllensten - Uppsala University
Goran Hallmans - Umeå University
Anna-Liisa Hartikainen - University of Oulu
Maija Hassinen - College Station Medical Center
Aki S. Havulinna - Natl Inst Hlth & Welf, Helsinki, Finland
Caroline Hayward - College Station Medical Center
Serge Hercberg - Université Paris Cité
Karl-Heinz Herzig - University of Oulu
Andrew A. Hicks - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Aroon D. Hingorani - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Joel N. Hirschhorn - Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
Albert Hofmanl - Erasmus MC
Jostein Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Oddgeir Lingaas Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Jouke-Jan Hottenga - University of Amsterdam
Phil Howard - UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London, England
Chao A. Hsiung - Biostat
Steven C. Hunt - University of Utah
M. Arfan Ikram - Erasmus MC
Thomas Illig - Helmholtz Zentrum München
Carlos Iribarren - Kaiser Permanente
Richard A. Jensen - University of Washington
Mika Kahonen - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA USA
Hyun Min Kang - Biostat
Sekar Kathiresan - Supreme Council Of Health
Brendan J. Keating - University of Cambridge
Kay-Tee Khaw - Lung Institute
Yun Kyoung Kim - Natl Inst Hlth, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Chungcheongbuk Do, South Korea
Eric Kim - Biomed Research Institute
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Norman Klopp - Helmholtz Zentrum München
Genovefa Kolovou - College Station Medical Center
Pirjo Komulainen - College Station Medical Center
Jaspal S. Kooner - Ealing Hosp NHS Trust, Dept Cardiol, Southall, Middx, England
Gulum Kosova - Broad Institute
Ronald M. Krauss - University of Lausanne
Diana Kuh - Swiss Inst Bioinformat, Lausanne, Switzerland
Zoltan Kutalik - University of Eastern Finland
Johanna Kuusisto - College Station Medical Center
Kirsti Kvaloy - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Timo A. Lakka - College Station Medical Center
Nanette R. Lee - College Station Medical Center
I-Te Lee - College Station Medical Center
Wen-Jane Lee - Taichung Vet Gen Hosp, Cardiovasc Ctr, Taichung, Taiwan
Daniel Levy - Framingham Heart Study
Xiaohui Li - Biomed Research Institute
Kae-Woei Liang - Boston University
Honghuang Lin - Framingham Heart Study
Li Lin - College Station Medical Center
Jaana Lindstrom - Natl Inst Hlth & Welf, Helsinki, Finland
Stephane Lobbens - University of Lille
Satu Mannisto - Natl Inst Hlth & Welf, Helsinki, Finland
Gabriele Muller - College Station Medical Center
Martina Muller-Nurasyid - Helmholtz Zentrum München
Francois Mach - College Station Medical Center
Hugh S. Markus - Université Sorbonne Paris Nord
Eirini Marouli - Queen Mary University of London
Mark I. McCarthy - University of Oxford
Colin A. McKenzie - University of the West Indies
Pierre Meneton - University of Verona
Cristina Menni - College Station Medical Center
Andres Metspalu - University of Tartu
Vladan Mijatovic - Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland
Leena Moilanen - Supreme Council Of Health
May E. Montasser - Cittadella Univ Monseratto, IRGB, CNR, Cagliari, Italy
Andrew D. Morris - University of Dundee
Alanna C. Morrison - Tampere University
Antonella Mulas - University of Tampere
Ramaiah Nagaraja - NIA, Genet Lab, Intramural Res Program, US Natl Inst Hlth, Baltimore, MD 21224 USA
Narisu Narisu - College Station Medical Center
Kjell Nikus - NHLBI, Div Cardiovasc Sci, Bldg 10, Bethesda, MD 20892 USA
Christopher J. O'Donnell - Framingham Heart Study
Paul F. O'Reilly - University of Amsterdam
Ken K. Ong - University of Cambridge
Fred Paccaud - College Station Medical Center
Cameron D. Palmer - Boston Childrens Hosp, Div Endocrinol, Boston, MA USA
Afshin Parsa - Cittadella Univ Monseratto, IRGB, CNR, Cagliari, Italy
Nancy L. Pedersen - Karolinska Institutet
Brenda W. Penninx - Leiden University
Markus Perola - Natl Inst Hlth & Welf, Helsinki, Finland
Annette Peters - Helmholtz Zentrum München
Neil Poulter - University of Lübeck
Peter P. Pramstaller - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Bruce M. Psaty - University of Washington
Thomas Quertermous - Stanford University
Dabeeru C. Rao - Umeå University
Asif Rasheed - College Station Medical Center
N. William Rayner - University of Oxford
Frida Renstrom - Umeå University
Rainer Rettig - University of Ottawa
Kenneth M. Rice - Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada
Robert Roberts - South Karelia Cent Hosp, Lappeenranta, Finland
Lynda M. Rose - Brigham and Women's Hospital
Jacques Rossouw - Childrens Hosp Boston, Genet & Program Genom, Boston, MA USA
Nilesh J. Samani - University of Leicester
Serena Sanna - University of Tampere
Jouko Saramies - Tech Univ Munich, Munich, Germany
Heribert Schunkert - Deutsch Zentrum Herz Kreislauf Forsch DZHK, Munich, Germany
Sylvain Sebert - University of Oulu
Wayne H-H Sheu - College Station Medical Center
Young-Ah Shin - Natl Inst Hlth, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Chungcheongbuk Do, South Korea
Xueling Sim - Biostat
Johannes H. Smit - Leiden University
Albert V. Smith - Iceland Heart Assoc, Kopavogur, Iceland
Maria X. Sosa - Johns Hopkins University
Tim D. Spector - College Station Medical Center
Alena Stancakova - Royal Coll Surgeons Ireland, Mol & Cellular Therapeut, Dublin, Ireland
Alice V. Stanton - University of Cambridge
Kathleen E. Stirrups - Queen Mary University of London
Heather M. Stringham - Biostat
Johan Sundstrom - Uppsala University
Amy J. Swift - College Station Medical Center
Ann-Christine Syvanen - Uppsala University
E-Shyong Tai - Duke-NUS Medical School
Toshiko Tanaka - NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA
Kirill V. Tarasov - College Station Medical Center
Alexander Teumer - University of Leicester
Unnur Thorsteinsdottir - Amgen
Martin D. Tobin - Erasmus MC
Elena Tremoli - University of Milan
Andre G. Uitterlinden - Erasmus MC
Matti Uusitupa - Kuopio Univ Hosp, Res Unit, Kuopio, Finland
Ahmad Vaez - University of Groningen
Dhananjay Vaidya - College Station Medical Center
Cornelia M. van Duijn - Erasmus MC
Erik P. A. van Iperen - Netherlands Heart Institute
Ramachandran S. Vasan - Framingham Heart Study
Germaine C. Verwoert - Erasmus MC
Jarmo Virtamo - Natl Inst Hlth & Welf, Helsinki, Finland
Veronique Vitart - College Station Medical Center
Benjamin F. Voight - University of Lausanne
Peter Vollenweider - University of Strasbourg
Aline Wagner - Supreme Council Of Health
Louise V. Wain - Erasmus MC
Nicholas J. Wareham - University of Cambridge
Hugh Watldns - University of Oxford
Alan B. Weder - University of Groningen
Harm Jan Westra - Univ West Indies, Res Inst Trop Med, Epidemiol Res Unit, Kingston, Jamaica
Rainford Wilks - College Station Medical Center
Tom Wilsgaard - College Station Medical Center
James F. Wilson - University of Edinburgh
Tien Y. Wong - Singapore Eye Research Institute
Tsun-Po Yang - Queen Mary University of London
Jie Yao - Biomed Research Institute
Loic Yengo - Univ Lille 2, Lille, France
Weihua Zhang - Supreme Council Of Health
Jing Hua Zhao - University of Cambridge
Xiaofeng Zhu - Minist Hlth, Victoria, Seychelles
Pascal Bovet - College Station Medical Center
Richard S. Cooper - Loyola University Chicago
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Danish Saleheen - College Station Medical Center
Jong-Young Lee - Natl Inst Hlth, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Chungcheongbuk Do, South Korea
Paul Elliott - Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
Hinco J. Gierman - Stanford University
Cristen J. Willer - College Station Medical Center
Lude Franke
G. Kees Hovingh
Kent D. Taylor - Biomed Research Institute
George Dedoussis - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Peter Sever - University of Lübeck
Andrew Wong - Swiss Inst Bioinformat, Lausanne, Switzerland
Lars Lind - Uppsala University
Themistocles L. Assimes - Stanford University
Inger Njolstad - College Station Medical Center
Peter E. H. Schwarz - College Station Medical Center
Claudia Langenberg - University of Cambridge
Harold Snieder - University of Groningen
Mark J. Caulfield - Queen Mary University of London
E. Melander - Lund University
Markku Laakso - College Station Medical Center
Juha Saltevo - College Station Medical Center
Rainer Rauramaa - College Station Medical Center
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Helsinki, Finland
Erik Ingelsson - Stanford University
Terho Lehtimaki - Fimlab
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Walter Palmas - Columbia University
Winfried Marz - Synlab
Meena Kumar - UCL, Dept Epidemiol & Publ Hlth, Genet Epidemiol Grp, London, England
Veikko Salomaa - Natl Inst Hlth & Welf, Helsinki, Finland
Yii-Der I. Chen - Biomed Research Institute
Jerome I. Rotter - Biomed Research Institute
Philippe Froguel - Iceland Heart Assoc, Kopavogur, Iceland
Marjo-Riitta Jarvelin - University of Oulu
Edward G. Lakatta - College Station Medical Center
Kari Kuulasmaa - Natl Inst Hlth & Welf, Helsinki, Finland
Paul W. Franks - Umeå University
Anders Hamsten - Karolinska Institutet
H-Erich Wichmann - Helmholtz Zentrum München
Colin N. A. Palmer - University of Dundee
Kari Stefansson - Amgen
Paul M. Ridker - Brigham and Women's Hospital
Ruth J. F. Loos - University of Cambridge
Aravinda Chalcravarti - Johns Hopkins University
Panos Deloukas - Queen Mary University of London
Andrew P. Morris - University of Oxford
Christopher Newton-Cheh - Broad Institute
Patricia B. Munroe - Queen Mary University of London
CHARGE-HF Consortium
Publication Details: Nature genetics, Vol.48(10), pp.1171-1184
Publisher: Springer Nature
Number of pages: 14
Grant note: R03 HD062783; P2C HD050924; R03 HD061437 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) ZIAEY000401 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) R01 TW008288; RC1 TW008485; R01 TW005596 / FIC NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC) ZIAHL006001 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) UL1TR000124 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) RG/13/2/30098; PG/02/128; SP/10/6/28562; SP/04/002; RG/07/005/23633; RG08/008; FS/13/6/29977; SP/08/005/25115; RG/10/12/28456; RG2008/014; RG/14/5/30893 / British Heart Foundation ZIA EY000401; R01 EY018246; R01 EY014684 / NEI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) P30ES007033 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01 WH042119; N01 WH042123; N01WH32109; N01WH32112; N01WH32108; N01 WH032105; N01 WH042111; N01 WH042117; N01 WH032122; N01 WH042109; N01 WH042130; N01WH22110; N01 WH042132; N01 WH042116; N01 WH042126; N01 WH042115; N01 WH042118; N01WH32113; N01WH42108; N01 WH042125; N01 WH042131; N01 WH042107; N01 WH032118; N01 WH042129; N01WH32115; N01WH32101; N01WH42113; N01 WH044221; N01WH32100; N01 WH032119; N01WH32111; N01WH32106; N01 WH042112; N01 WH042122; N01 WH042120; N01 WH042110; N01 WH042121; N01WH24152 / WHI NIH HHS RC2MH089951 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) N01 WH42124 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MC_PC_U127561128 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) UM1 CA182913 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 AG023629; ZIA AG007380; R01 AG018728; R01 AG015928; R01 AG016592; N01 AG062106; Z01 AG000513; R01 AG032098; R01 AG027058; R01 AG020098; N01AG12109; N01 AG062103; N01 AG012100; R01 AG028555; R01 AG013196; R01 AG025941; N01 AG062101; T32 AG000219; HHSN271201200022C; R01 AG010175 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden P30 ES010126; P30 ES007033 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 090532/Z/09/Z; 081917/Z/07/Z; WT098017; 085475/B/08/Z; 098051; 068545/Z/02; 084723/Z/08/Z / Wellcome Trust; European Commission N01HG65403; HHSN268200782096C; Z01 HG000024; U01 HG007416; Z01 HG200362; U01 HG004402 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) P30 DK063491; P30 DK056350; P30 DK020572; P30 DK072488; R01 DK101478; R01 DK054261; R01 DK084350; R01 DK079888; R01 DK093757; P60 DK079637; R01 DK062370; R01 DK072193; R01 DK078150; U01 DK062370 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UM1CA182913 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation U01GM074518 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) NF-SI-0512-10113 / National Institute for Health Research; National Institute for Health Research (NIHR) R03HD062783 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Chief Scientist Office P2CHD050924 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) N01HC005187 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) M01 RR016500; UL1 RR025005; M01 RR000425; U54 RR020278; P20 RR020649; UL1 RR033176; M01 RR000052; UL1 RR024156; M01 RR010284; UL1 RR025774; UL1 RR024975 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) N01WH042125 / WOMEN'S HEALTH INITIATIVE - OFFICE OF THE DIRECTOR NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RC1TW008485 / FOGARTY INTERNATIONAL CENTER; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC) U01HG004402 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) Z01AG000513 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) UL1RR033176 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) U01NS041588 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) UL1 TR000124 / NCATS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) U01 NS041588; R21 NS064908 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) G0700931; MC_UU_12015/1; G0000934; G1002319; G0601261; MC_PC_U127561128; G0401527; G0600705; MR/N015746/1; G0500539; MR/L003120/1; 85374; MC_UU_12019/1; MC_UU_12013/5; MR/K006584/1; MR/L01341X/1; MR/K013351/1; G9521010D; MR/N003284/1; G1000143; G0601966; G0600237 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission MC_UU_12013/3 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission R01 MH063706; RC2 MH089951; RL1 MH083268 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01DK101478 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01 GM074518; S06 GM008016 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) N01 HC048050; U01 HL054495; N01HC55020; R01 HL055673; HHSN268201100010C; R01 HL120393; RC2 HL101834; U01 HL096917; R01 HL036310; N01 HC048048; N01 HC045205; N01 HC048047; U01 HL054472; U01 HL072518; R01 HL075366; R01 HL085144; R01 HL085251; N01HC95162; T32 HL007902; N01HC85082; N01 HC085084; R01 HL098283; U01 HL054497; R01 HL077477; N01 HC055018; U01 HL054471; N01 HC035129; R01 HL105756; U01 HL084756; R01 HL059684; R01 HL086694; N01 WH42114; T32 HL007208; N01HC95165; N01HC55016; N01WH32102; N01 HC055019; R01 HL093328; N01 HC045134; N01HC95168; R01 HL087698; N01HC55222; K99 HL094535; T32 HL098049; N01HC55021; N01HC85079; R01 HL080295; N01 HC095095; N01HC95169; R01 HL059367; N01HC95167; N01HC85083; N01 HC045133; U01 HL054496; R01 HL046380; N01HC95159; N01HC95163; R01 HL103612; N01HC85086; N01 HC015103; HHSN268201100011C; N01 HC055015; R01 HL053353; HHSN268201100012C; R01 HL122684; N01HC75150; R01 HL093029; K23 HL080025; N01 HC085085; R01 HL043851; K24 HL004334; N01HC25195; R01 HL080467; R01 HL087660; HHSN268201200036C; N01 HC005187; N01HC65226; U01 HL069757; HHSN268201100008C; HHSN268201100005C; HHSN268201100007C; N01HC95161; U01 HL080295; R01 HL109512; R01 HL088119; N01 HC045204; R01 HL087647; N01HC85080; N01HC95164; R01 HL074166; R21 HL123677; R01 HL087641; HHSN268201100009C; N02HL64278; N01 HC048049; R01 HL087679; R01 HL087652; RC1 HL100245; N01HC95166; HHSN268201100006C; U01 HL072515; R01 HL071025; N01HC85081; R01 HL109946; U01 HL054509; U01 HL054473; N01HC95160; R01 HL113933 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Arthritis Research UK; Versus Arthritis
Identifiers: 9939029008331
Academic Unit: King Abdulaziz University; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article