The genome of the social amoeba Dictyostelium discoideum

L. Eichinger; J.A. Pachebat; G. Glöckner; M.-A. Rajandream; R. Sucgang; M. Berriman; J. Song; R. Olsen; K. Szafranski; Q. Xu; B. Tunggal; S. Kummerfeld; M. Madera; B. A. Konfortov; F. Rivero; A. T. Bankier; R. Lehmann; N. Hamlin; R. Davies; P. Gaudet; P. Fey; K. Pilcher; G. Chen; D. Saunders; E. Sodergren; P. Davis; A. Kerhornou; X. Nie; N. Hall; C. Anjard; L. Hemphill; N. Bason; P. Farbrother; B. Desany; E. Just; T. Morio; R. Rost; C. Churcher; J. Cooper; S. Haydock; N. van Driessche; A. Cronin; I. Goodhead; D. Muzny; T. Mourier; A. Pain; M. Lu; D. Harper; R. Lindsay; H. Hauser; K. James; M. Quiles; M. Madan Babu; T. Saito; C. Buchrieser; A. Wardroper; M. Felder; M. Thangavelu; D. Johnson; A. Knights; H. Loulseged; K. Mungall; K. Oliver; C. Price; M.A. Quail; H. Urushihara; J. Hernandez; E. Rabbinowitsch; D. Steffen; M. Sanders; J. Ma; Y. Kohara; S. Sharp; M. Simmonds; S. Spiegler; A. Tivey; S. Sugano; B. White; D. Walker; J. Woodward; T. Winckler; Y. Tanaka; G. Shaulsky; M. Schleicher; G. Weinstock; A. Rosenthal; E.C. Cox; R. L. Chisholm; R. Gibbs; W. F. Loomis; M. Platzer; R. R. Kay; J. Williams; P. H. Dear; A. A. Noegel; B. Barrell; A. Kuspa

doi:10.1038/nature03481

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The genome of the social amoeba Dictyostelium discoideum

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The genome of the social amoeba Dictyostelium discoideum

L. Eichinger, J.A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, …

Nature (London), Vol.435(7038), pp.43-57

05/05/2005

DOI: https://doi.org/10.1038/nature03481

PMCID: PMC1352341

PMID: 15875012

Abstract

The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum . The gene-dense chromosomes encode ~12,500 predicted proteins, a high proportion of which have long repetitive amino acid tracts. There are many genes for polyketide synthases and ABC transporters, suggesting an extensive secondary metabolism for producing and exporting small molecules. The genome is rich in complex repeats, one class of which is clustered and may serve as centromeres. Partial copies of the extrachromosomal rDNA element are found at the ends of each chromosome, suggesting a novel telomere structure and the use of a common mechanism to maintain both the rDNA and chromosomal termini. A proteome-based phylogeny shows that the amoebozoa diverged from the animal/fungal lineage after the plant/animal split, but Dictyostelium appears to have retained more of the diversity of the ancestral genome than either of these two groups.

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Title: The genome of the social amoeba Dictyostelium discoideum
Creators - without role: L. Eichinger - University of Cologne
J.A. Pachebat - MRC Laboratory of Molecular Biology
G. Glöckner - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
M.-A. Rajandream - Wellcome Sanger Institute
R. Sucgang - Baylor College of Medicine
M. Berriman - Wellcome Sanger Institute
J. Song - Baylor College of Medicine
R. Olsen - University of California, San Diego
K. Szafranski - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
Q. Xu - Baylor College of Medicine
B. Tunggal - University of Cologne
S. Kummerfeld - MRC Laboratory of Molecular Biology
M. Madera - MRC Laboratory of Molecular Biology
B. A. Konfortov - MRC Laboratory of Molecular Biology
F. Rivero - University of Cologne
A. T. Bankier - MRC Laboratory of Molecular Biology
R. Lehmann - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
N. Hamlin - Wellcome Sanger Institute
R. Davies - Wellcome Sanger Institute
P. Gaudet - Northwestern University
P. Fey - Northwestern University
K. Pilcher - Northwestern University
G. Chen - Baylor College of Medicine
D. Saunders - Wellcome Sanger Institute
E. Sodergren - Baylor College of Medicine
P. Davis - Wellcome Sanger Institute
A. Kerhornou - Wellcome Sanger Institute
X. Nie - Baylor College of Medicine
N. Hall - Wellcome Sanger Institute
C. Anjard - University of California, San Diego
L. Hemphill - Baylor College of Medicine
N. Bason - Wellcome Sanger Institute
P. Farbrother - University of Cologne
B. Desany - Baylor College of Medicine
E. Just - Northwestern University
T. Morio - University of Tsukuba
R. Rost - Ludwig-Maximilians-Universität München
C. Churcher - Wellcome Sanger Institute
J. Cooper - Wellcome Sanger Institute
S. Haydock - University of Cambridge
N. van Driessche - Baylor College of Medicine
A. Cronin - Wellcome Sanger Institute
I. Goodhead - Wellcome Sanger Institute
D. Muzny - Baylor Genetics
T. Mourier - Wellcome Sanger Institute
A. Pain - Wellcome Sanger Institute
M. Lu - Baylor College of Medicine
D. Harper - Wellcome Sanger Institute
R. Lindsay - Baylor College of Medicine
H. Hauser - Wellcome Sanger Institute
K. James - Wellcome Sanger Institute
M. Quiles - Baylor Genetics
M. Madan Babu - MRC Centre
T. Saito - Hokkaido University
C. Buchrieser - Institut Pasteur
A. Wardroper - MRC Laboratory of Molecular Biology
M. Felder - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
M. Thangavelu - Hutchison/MRC Research Centre
D. Johnson - Wellcome Sanger Institute
A. Knights - Wellcome Sanger Institute
H. Loulseged - Baylor Genetics
K. Mungall - Wellcome Sanger Institute
K. Oliver - Wellcome Sanger Institute
C. Price - Wellcome Sanger Institute
M.A. Quail - Wellcome Sanger Institute
H. Urushihara - University of Tsukuba
J. Hernandez - Baylor Genetics
E. Rabbinowitsch - Wellcome Sanger Institute
D. Steffen - Baylor Genetics
M. Sanders - Wellcome Sanger Institute
J. Ma - Baylor College of Medicine
Y. Kohara - National Institute of Genetics
S. Sharp - Wellcome Sanger Institute
M. Simmonds - Wellcome Sanger Institute
S. Spiegler - Wellcome Sanger Institute
A. Tivey - Wellcome Sanger Institute
S. Sugano - The University of Tokyo
B. White - Wellcome Sanger Institute
D. Walker - Wellcome Sanger Institute
J. Woodward - Wellcome Sanger Institute
T. Winckler - Goethe University Frankfurt
Y. Tanaka - University of Tsukuba
G. Shaulsky - Baylor College of Medicine
M. Schleicher - Ludwig-Maximilians-Universität München
G. Weinstock - Baylor College of Medicine
A. Rosenthal - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
E.C. Cox - Princeton University
R. L. Chisholm - Northwestern University
R. Gibbs - Baylor College of Medicine
W. F. Loomis - University of California, San Diego
M. Platzer - Genome Analysis, Institute for Molecular Biotechnology, Beutenbergstr. 11, D-07745 Jena, Germany
R. R. Kay - MRC Laboratory of Molecular Biology
J. Williams - University of Dundee
P. H. Dear - MRC Laboratory of Molecular Biology
A. A. Noegel - University of Cologne
B. Barrell - Wellcome Sanger Institute
A. Kuspa - Baylor College of Medicine
Publication Details: Nature (London), Vol.435(7038), pp.43-57
Identifiers: 9943542708331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article