Abstract
Paracetamol (PCM) is one of the most commonly employed drugs for the treatment of fever and pain. The activity of the drug is dependent on the excipients utilized during formulation as well as on physiological conditions. Herein, the conductivity measurements are implied to deduce the possible molecular interactions occurring between sodium dodecyl sulfate (SDS) and PCM in the presence of ZnSO4 at various temperatures. The critical micelle concentration (cmc) of SDS was found to be lowered with the augmentation of PCM concentration. The cmc values of the SDS + PCM mixture were found to be reduced with the increase of temperature and concentration of ZnSO4. The counterion binding values were found to be temperature and additives dependent. The estimated values of free energies of micellization (Delta G(m)(o)) signify the spontaneous aggregation of SDS + PCM mixture in all media studied. The spontaneity of self-assembly for SDS + PCM mixture augmented at a higher temperature. The estimated values of enthalpy of micellization (Delta H-m(o)) and entropy of micellization (Delta S-m(o)) were positive throughout. The values of Delta H-m(o) and Delta S-m(o) exhibit excellent linearity. The values of different transfer energies, intrinsic enthalpies, and compensation temperature were also calculated and explained properly.