Abstract
Gentamicin (GM) is a commonly prescribed antimicrobial drug used for treatment of infections but associated hepatic and renal complications restrict its efficacy. Overproduction of free radicals and inflammation are involved in GM-induced hepato-renal damage. Date palm is renowned to have antioxidant and anti-inflammatory bioactive composites. In this context, the current research was purposed to assess the ameliorative influence of date palm extract (DE) supplementation against GM-induced hepato-renal injury. Gas chromatography-mass spectrometry (GC–MS) was used to detect the bioactive constitutes in DE. The protective action of high and low doses of DE was assessed alongside the GM remediation (80 mg/kg) in rats. GM evoked significant alterations in liver and kidney function biomarkers (aminotransferases, albumin, creatinine, and blood urea). Furthermore, notable elevations in malondialdehyde (MDA) level and increment expression of inducible nitric oxide synthase (iNOS) along with reduction in catalase (CAT) activity were observed in both organs after GM treatment. Oxidative stress was the main modulatory mechanism in GM-induced hepato-renal toxicity. However, DE could mitigate the GM-inflicted liver and kidney damage, in a dose-response pattern, due to its high content of phenolics and flavonoids.
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•Gentamicin -induced hepatorenal toxicity is mediated by lipid peroxidation.•Date palm extract alleviates gentamicin-inflicted hepatorenal toxicity in a dose-dependent pattern.•Antioxidant mechanisms are involved in such alleviation.•Date palm extract have anti-inflammatory and anti-apoptotic effect.•Date supplementation has therapeutic potential in patients receiving GM regimen.