Abstract
(
or RV) is an annual plant having rounded leaves, with flowers containing seeds. RV protects liver, resists cancer, and removes free radicals in cells. The aim of this study was to illustrate the effect of the
water seeds extract (RVWSE) treatment on mice before and during pregnancy, and its action on the liver and kidney histology and enzymes, aspartate aminotransferase and alanine aminotransferase, the blood urea nitrogen, the creatinine, and the uric acid. The seeds of
were collected, extracted, and its component analyzed via Gas chromatography mass spectrometry. Mice treated with 10 mg kg
RVWSE via feeding tube for 1 week before mating, or during pregnancy. The number of offspring or litter size was recorded and the blood sample was collected at the end of the experiment to test the kidney and liver enzymes, and their histology. Results showed that RVWSE contains different phytochemicals consisting of some hexane and chloroform compounds. The fertility rate of 1st treated pre-pregnancy group is 30% and the 2nd group is 35%. The offspring rate of 1st treated group showed higher new born rate (8 new born/female) than 2nd treated group (5.4 new born/female). The blood enzyme levels of the kidney and liver showed some variation between the two groups and their histology illustrates some non-significant variation between the treated and control groups of mice. The implications of the results of this study illustrate the safe use of the RVWSE, its effectiveness in improving mice fertility, and positive impact on biomarker of serum enzymes of liver and kidney with their histopathology.