Abstract
METHODS AND RESULTS:Acute oral administration of various doses of α-tocopherol (100, 600, 1200mg/kg by mouth) produced a dose dependent and significant protection of mucosal injury induced by ischaemia-reperfusion injury in experimental animals. In addition, intraperitoneal administration of calcium channel blockers, nifedipine (0.5, 1, 3 mg/kg), diltiazem (1.25, 2.5 mg/kg) and verapamil (1.25, 2.5, 5, 10 mg/kg) protected gastric mucosa in ischaemia-reperfusion. α-Tocopherol (100 mg/kg by mouth), when given in combination with either nifedipine (0.5 mg/kg intraperitoneally), diltiazem (1.25 mg/kg intraperitoneally) or verapamil (1.25 mg/kg intraperitoneally), significantly reduced gastric mucosal injury. The protective effect of calcium channel blockers and the antioxidant agent was synergistic.
CONCLUSION:The results showed that calcium channel blockers potentiate the protective effect of the antioxidant activity of α-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion in experimental animals.European Journal of Gastroenterology & Hepatology 1996, 8:1107–1110