Abstract
PurposeTo investigate whether higher dietary inflammatory index (DII (R)) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database.MethodsA total of4358 community-dwelling participants (2527 females; mean age 61.2years) from the Osteoarthritis Initiative were identified. DII (R) scores werecalculated using the validated Block Brief 2000 Food-Frequency Questionnaire andscores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII (R)) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results werereported as odds ratios (ORs) with 95% confidence intervals (CIs).ResultsParticipants with a higher DII (R) score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII (R) score (quartile 4: 35.4% vs. quartile 1: 24.0%; p<0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII (R) score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14-1.72; p=0.002) compared to participants with the lowest DII (R) score (quartile 1).ConclusionsHigher DII (R) values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.