Abstract
Soluplus (R) is a graft amphiphilic copolymer that is frequently used as an excipient in solid dosage forms as a dissolution and a solubility enhancer. We discovered that Soluplus (R) can be dissolved in vitamin E. The result is a tacky and highly adhesive material. Our research objective was to evaluate the rheological, adhesive, and textural properties of the Soluplus (R)/Vitamin E composites. In this study, Soluplus (R) was dissolved under heat in vitamin E at increasing concentrations from 0 to 40% (by weight). The flow behavior of the Soluplus (R)/Vitamin E composites was determined by applying shear stress using an advanced AR2000 rheometer. Under the linear viscoelastic region (LVR), the rheological properties of the blends such as dynamic viscosity (eta'), storage modulus (G'), loss modulus (G ''), and the phase angle tangent (tan delta) were measured. Hardness, adhesiveness, and cohesiveness of the blends were also measured with a TA.XT plus texture analyzer. Rheological analysis showed that the viscosity of the Soluplus (R)/Vitamin E composites increased with an increase in Soluplus (R) concentration but decreased as the temperature increased from 20 to 90 degrees C. The adhesiveness of the blends also significantly increased with an increase in Soluplus (R) concentration. The results from this study indicated that Soluplus (R)/Vitamin E composites have the potential to be exploited in applications where the use of highly adhesive material is desirable.