Abstract
BRAF-activated noncoding RNA (BANCR) was found in some studies to act as an oncogene and in others as a tumor suppressor. We aimed to study the role of lncRNA BANCR in esophageal cancer, its expression in cancer tissues, and the plasma of the patients and it's possible to use a non-invasive molecular marker for prognosis and survival. lncRNA BANCR expression was assessed by qRT-PCR in tumor tissues and the plasma of 77 patients with esophageal cancer. lncRNA BANCR was overexpressed in the tumor tissues and the plasma of patients. Its overexpression was significantly linked to adverse clinical and pathological features and short overall survival. In esophageal cancer, lncRNA BANCR was found to act as an oncogene. The expression and specificity of lncRNA BANCR in the plasma of esophageal cancer patients make it a possible prognostic non-invasive molecular marker.