Abstract
Background Dendritic cells (DCs) play a key role in shaping T cell responses. To do this, DCs must be able to migrate to the site of the infection and the lymph nodes to prime T cells and initiate the appropriate immune response. Integrins such as beta(2) integrin play a key role in leukocyte adhesion, migration, and cell activation. However, the role of beta(2) integrin in DC migration and function in the context of infection-induced inflammation in the gut is not well understood. This study looked at the role of beta(2) integrin in DC migration and function during infection with the nematode worm Trichuris muris. Itgb2(tm1Bay) mice lacking functional beta(2) integrin and WT littermate controls were infected with T. muris and the response to infection and kinetics of the DC response was assessed. Results In infection, the lack of functional beta(2) integrin significantly reduced DC migration to the site of infection but not the lymph nodes. The lack of functional beta(2) integrin did not negatively impact T cell activation in response to T. muris infection. Conclusions This data suggests that beta(2) integrins are important in DC recruitment to the infection site potentially impacting the initiation of innate immunity but is dispensible for DC migration to lymph nodes and T cell priming in the context of T. muris infection.