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The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?
Journal article   Open access

The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?

Amr Omer, Sergio Di Marco and Imed-Eddine Gallouzi
Molecular & cellular oncology, Vol.8(1), pp.1850161-1850161
11/01/2021
DOI: https://doi.org/10.1080/23723556.2020.1850161
PMCID: 7849692
PMID: 33553605

Abstract

SASPs Senescence cancer progression G3BP1
Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
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https://doi.org/10.1080/23723556.2020.1850161View
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