Abstract
From what began as a casual discovery of the ketene-Claisen rearrangement (the Malherbe-Bellus rearrangement) over 3 decades ago has flourished a reaction of substantial significance. The noticeable qualities of the ketene-Claisen rearrangement is accomplished in terms of experimental simplicity, forming new C-C bonds, high levels of chemo-and stereocontrol, ring enlargements and constructing new stereocenters. This survey of the ketene-Claisen rearrangement with some applications in organic synthesis will not only recapitulate the prospective of this reaction so far but also illustrate the achievable future significant prospective. (C) 2017 Elsevier Ltd. All rights reserved.