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The stereoselective total synthesis of (+)-18-(6S,9R,10R)-bovidic acid
Journal article   Peer reviewed

The stereoselective total synthesis of (+)-18-(6S,9R,10R)-bovidic acid

J. S. Yadav, K. Ramesh, U. V. Subba Reddy, B. V. Subba Reddy and Ahamad Al Khazim Al Ghamdi
Tetrahedron letters, Vol.52(23), pp.2943-2945
08/06/2011
DOI: https://doi.org/10.1016/j.tetlet.2011.03.089

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An expedient stereoselective total synthesis of 18-carbon (+)-(6S,9R,10R)-bovidic acid, isolated from the pelage and skin of a gaur B. frontalis is described using L-proline catalysed sequential alpha-aminoxylation and Horner-Wadsworth-Emmons olefination of aldehyde, cross metathesis and tandem Sharpless asymmetric dihydroxylation-S(N)2 cyclization reaction as the key steps. (C) 2011 Published by Elsevier Ltd.

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