Abstract
Four different proteins have been identified on high resolution two dimensional gels of [
35S] methionine labelled human cervical biopsies whose expression correlates with the presence of papillomavirus. They are all basic proteins having molecular weights in the region of 48 to 50 kd and are normally expressed individually in different lesions unless the lesion results from a co-infection of two virus types.
Comparison of the occurrence of these marker proteins with the actual HPV type present, determined by
in situ filter hybridisation, has shown that two are found exclusively with HPV types
6
11
while the other two are found with types
16
18
.