Abstract
Background: Only a handful of clinical parameters other than body weight are used in managing LBW newborns with perforated necrotizing enterocolitis (NEC). Here, we determined clinical use of score for neonatal acute physiology-perinatal extension (SNAPPE II) score in the surgical decision, peritoneal drain (PD) vs PD + laparotomy in low birth weight (LBW) newborns with perforated NEC.
Patients and Method: A retrospective study of all neonates weighing less than 1500 g with the diagnosis of perforated NEC between 2000 and 2006 was performed. Patients were categorized in 2 groups-PD alone vs PD + laparotomy. The SNAPPE score was calculated at various days of clinical evolution. The primary outcome of mortality was used, and comparisons using univariate and multivariate analyses were performed.
Results: Of 39 patients identified, 20 were treated with PD alone, whereas 19 bad PD and laparotomy. The mean gestational age (25.6 vs 26.6 weeks) and the mean birth weight (795 vs 910 g) were comparable (P >.05). There were no differences between PD group and LAP group with regard to SNAPPE scores calculated on the day of admission (P =.057), the day before the drain insertion (P =. 167) and the day after the drain insertion (P =.66). When considering survival as the dependent variable while controlling for the treatment assignment, the modified SNAPPE score after PD drain insertion in group PD was significantly higher than in the PD + laparotomy group (21.4 vs 9.47; P =.009).
Conclusion: The modified SNAPPE score is a good predictor of mortality after the PD insertion. A postPD insertion, high SNAPPE value was correlated with increased mortality regardless of an additional laparotomy. External validation of the modified SNAPPE score in a large patient population is required before its use in guiding treatment decisions. 0-2008 Elsevier Inc. All rights reserved.