The vaginal microbiome and preterm birth

Jennifer M. Fettweis; Myrna G. Serrano; J. Paul Brooks; David J. Edwards; Philippe H. Girerd; Hardik I. Parikh; Bernice Huang; Tom J. Arodz; Laahirie Edupuganti; Abigail L. Glascock; Jie Xu; Nicole R. Jimenez; Stephany C. Vivadelli; Stephen S. Fong; Nihar U. Sheth; Sophonie Jean; Vladimir Lee; Yahya A. Bokhari; Ana M. Lara; Shreni D. Mistry; Robert A. Duckworth; Steven P. Bradley; Vishal N. Koparde; X. Valentine Orenda; Sarah H. Milton; Sarah K. Rozycki; Andrey V. Matveyev; Michelle L. Wright; Snehalata V. Huzurbazar; Eugenie M. Jackson; Ekaterina Smirnova; Jonas Korlach; Yu-Chih Tsai; Molly R. Dickinson; Jamie L. Brooks; Jennifer I. Drake; Donald O. Chaffin; Amber L. Sexton; Michael G. Gravett; Craig E. Rubens; N. Romesh Wijesooriya; Karen D. Hendricks-Munoz; Kimberly K. Jefferson; Jerome F. Strauss; Gregory A. Buck

doi:10.1038/s41591-019-0450-2

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The vaginal microbiome and preterm birth

Journal article

Open access

Peer reviewed

The vaginal microbiome and preterm birth

Jennifer M. Fettweis, Myrna G. Serrano, J. Paul Brooks, David J. Edwards, Philippe H. Girerd, Hardik I. Parikh, Bernice Huang, Tom J. Arodz, Laahirie Edupuganti, Abigail L. Glascock, …

Nature medicine, Vol.25(6), pp.1012-1021

01/06/2019

DOI: https://doi.org/10.1038/s41591-019-0450-2

PMCID: PMC6750801

PMID: 31142849

Abstract

Biochemistry & Molecular Biology

Cell Biology

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes 'omics' data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.

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Title: The vaginal microbiome and preterm birth
Creators - without role: Jennifer M. Fettweis - Virginia Commonwealth University
Myrna G. Serrano - Virginia Commonwealth University
J. Paul Brooks - Virginia Commonwealth University
David J. Edwards - Virginia Commonwealth University
Philippe H. Girerd - Virginia Commonwealth University
Hardik I. Parikh - Virginia Commonwealth University
Bernice Huang - Virginia Commonwealth University
Tom J. Arodz - Virginia Commonwealth University
Laahirie Edupuganti - Virginia Commonwealth University
Abigail L. Glascock - Virginia Commonwealth University
Jie Xu - Virginia Commonwealth University
Nicole R. Jimenez - Virginia Commonwealth University
Stephany C. Vivadelli - Virginia Commonwealth University
Stephen S. Fong - Virginia Commonwealth University
Nihar U. Sheth - Virginia Commonwealth University
Sophonie Jean - Virginia Commonwealth University
Vladimir Lee - Virginia Commonwealth University
Yahya A. Bokhari - Virginia Commonwealth University
Ana M. Lara - Virginia Commonwealth University
Shreni D. Mistry - Virginia Commonwealth University
Robert A. Duckworth - Virginia Commonwealth University
Steven P. Bradley - Virginia Commonwealth University
Vishal N. Koparde - Virginia Commonwealth University
X. Valentine Orenda - Virginia Commonwealth University
Sarah H. Milton - Virginia Commonwealth University
Sarah K. Rozycki - Virginia Commonwealth University
Andrey V. Matveyev - Virginia Commonwealth University
Michelle L. Wright - Emory University
Snehalata V. Huzurbazar - West Virginia University
Eugenie M. Jackson - West Virginia University
Ekaterina Smirnova - Virginia Commonwealth University
Jonas Korlach - Pacific Biosciences
Yu-Chih Tsai - Pacific Biosciences
Molly R. Dickinson - Virginia Commonwealth University
Jamie L. Brooks - Virginia Commonwealth University
Jennifer I. Drake - Virginia Commonwealth University
Donald O. Chaffin - Global Alliance to Prevent Prematurity and Stillbirth
Amber L. Sexton - Global Alliance to Prevent Prematurity and Stillbirth
Michael G. Gravett - University of Washington
Craig E. Rubens - Global Alliance to Prevent Prematurity and Stillbirth
N. Romesh Wijesooriya - Virginia Commonwealth University
Karen D. Hendricks-Munoz - Virginia Commonwealth University
Kimberly K. Jefferson - Virginia Commonwealth University
Jerome F. Strauss - Virginia Commonwealth University
Gregory A. Buck - Virginia Commonwealth University
Publication Details: Nature medicine, Vol.25(6), pp.1012-1021
Publisher: NATURE PORTFOLIO
Number of pages: 28
Grant note: GAPPS BMGF PPB grant UH3AI083263; U54HD080784; R21HD092965; 1R01HD092415 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Center for Complementary and Integrative Health Common Fund 1453658 / NSF; National Science Foundation (NSF) Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Office of Research on Women's Health (ORWH)
Identifiers: 9921369808331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article