Abstract
This study is conducted to investigate the influence of oral theophylline administration (100 mg/kg bw per day) on the activity of carnitine palmitoyltransferase (CPT) in cardiac tissues of rats for 5-week interval treatments. Results showed significant increase in the activity of CPT was observed in cardiac tissues of theophylline-treated groups as compared to either control or placebo groups. Moreover, the results showed positive correlations between the cardiac concentrations of long-chain acylcarnitine (LC) and the activity of CPT and between plasma concentrations of LC and the cardiac concentrations of LC (
P<0.01), respectively. The observed changes in activity of cardiac CPT might be due to the result from theophylline- enhanced decrease the sensitivity of CPT to inhibition by malonyl-CoA and/or from theophylline-enhanced mobilization of lipid from adipose tissues which consequently stimulated an increased carnitine transport into the tissues to form palmitoylcarnitine groups for subsequent β-oxidation inside the mitochondria. Thus, these accumulations of acylcarnitine groups in mitochondria may increase the catalytic action of CPT.